Cleaved CD44 intracellular domain supports activation of stemness factors and promotes tumorigenesis of breast cancer

CD44 plays a role in the progression of tumors and is expressed in cancer stem cells (CSCs). However, the mechanisms underlying the crosstalk of CD44 with stemness genes in CSC maintenance remains unclear. In this study, we demonstrated how the cleaved intracellular domain of CD44 (CD44ICD) activate...

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Detalles Bibliográficos
Autores principales: Cho, Yunhee, Lee, Hyun-Woo, Kang, Hyeok-Gu, Kim, Hye-Young, Kim, Seok-Jun, Chun, Kyung-Hee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4496178/
https://www.ncbi.nlm.nih.gov/pubmed/25909162

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