WIP1 stimulates migration and invasion of salivary adenoid cystic carcinoma by inducing MMP-9 and VEGF-C

The wild-type p53 induced phosphatase 1 (WIP1) is an oncogene overexpressed in a variety of human cancers. Here, we demonstrated that WIP1 silencing reduced MMP-9 and VEGF-C expression as well as migration and invasion of salivary adenoid cystic carcinoma (ACC) cells. Overexpression of MMP-9 or VEGF...

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Autores principales: Tang, Ya-ling, Liu, Xin, Gao, Shi-yu, Feng, Hao, Jiang, Ya-ping, Wang, Sha-sha, Yang, Jing, Jiang, Jian, Ma, Xiang-rui, Tang, Ya-jie, Chen, Yu, Liang, Xin-hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4496200/
https://www.ncbi.nlm.nih.gov/pubmed/25797250
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author Tang, Ya-ling
Liu, Xin
Gao, Shi-yu
Feng, Hao
Jiang, Ya-ping
Wang, Sha-sha
Yang, Jing
Jiang, Jian
Ma, Xiang-rui
Tang, Ya-jie
Chen, Yu
Liang, Xin-hua
author_facet Tang, Ya-ling
Liu, Xin
Gao, Shi-yu
Feng, Hao
Jiang, Ya-ping
Wang, Sha-sha
Yang, Jing
Jiang, Jian
Ma, Xiang-rui
Tang, Ya-jie
Chen, Yu
Liang, Xin-hua
author_sort Tang, Ya-ling
collection PubMed
description The wild-type p53 induced phosphatase 1 (WIP1) is an oncogene overexpressed in a variety of human cancers. Here, we demonstrated that WIP1 silencing reduced MMP-9 and VEGF-C expression as well as migration and invasion of salivary adenoid cystic carcinoma (ACC) cells. Overexpression of MMP-9 or VEGF-C restored migration and invasion in WIP1 knockdown cells, indicating that MMP-9 and VEGF-C are downstream targets of WIP1 signaling. Levels of cyclin D1 and c-Myc, targets of Wnt/β-catenin pathway, were significantly decreased by WIP1 silencing. In addition, WIP1 expression was positively associated with metastasis and prognosis of ACC patients as well as with MMP-9 or VEGF-C in ACC tissues.
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spelling pubmed-44962002015-07-10 WIP1 stimulates migration and invasion of salivary adenoid cystic carcinoma by inducing MMP-9 and VEGF-C Tang, Ya-ling Liu, Xin Gao, Shi-yu Feng, Hao Jiang, Ya-ping Wang, Sha-sha Yang, Jing Jiang, Jian Ma, Xiang-rui Tang, Ya-jie Chen, Yu Liang, Xin-hua Oncotarget Research Paper The wild-type p53 induced phosphatase 1 (WIP1) is an oncogene overexpressed in a variety of human cancers. Here, we demonstrated that WIP1 silencing reduced MMP-9 and VEGF-C expression as well as migration and invasion of salivary adenoid cystic carcinoma (ACC) cells. Overexpression of MMP-9 or VEGF-C restored migration and invasion in WIP1 knockdown cells, indicating that MMP-9 and VEGF-C are downstream targets of WIP1 signaling. Levels of cyclin D1 and c-Myc, targets of Wnt/β-catenin pathway, were significantly decreased by WIP1 silencing. In addition, WIP1 expression was positively associated with metastasis and prognosis of ACC patients as well as with MMP-9 or VEGF-C in ACC tissues. Impact Journals LLC 2015-03-05 /pmc/articles/PMC4496200/ /pubmed/25797250 Text en Copyright: © 2015 Tang et al. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
Tang, Ya-ling
Liu, Xin
Gao, Shi-yu
Feng, Hao
Jiang, Ya-ping
Wang, Sha-sha
Yang, Jing
Jiang, Jian
Ma, Xiang-rui
Tang, Ya-jie
Chen, Yu
Liang, Xin-hua
WIP1 stimulates migration and invasion of salivary adenoid cystic carcinoma by inducing MMP-9 and VEGF-C
title WIP1 stimulates migration and invasion of salivary adenoid cystic carcinoma by inducing MMP-9 and VEGF-C
title_full WIP1 stimulates migration and invasion of salivary adenoid cystic carcinoma by inducing MMP-9 and VEGF-C
title_fullStr WIP1 stimulates migration and invasion of salivary adenoid cystic carcinoma by inducing MMP-9 and VEGF-C
title_full_unstemmed WIP1 stimulates migration and invasion of salivary adenoid cystic carcinoma by inducing MMP-9 and VEGF-C
title_short WIP1 stimulates migration and invasion of salivary adenoid cystic carcinoma by inducing MMP-9 and VEGF-C
title_sort wip1 stimulates migration and invasion of salivary adenoid cystic carcinoma by inducing mmp-9 and vegf-c
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4496200/
https://www.ncbi.nlm.nih.gov/pubmed/25797250
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