Dual inhibition of HDAC and EGFR signaling with CUDC-101 induces potent suppression of tumor growth and metastasis in anaplastic thyroid cancer

Anaplastic thyroid cancer (ATC) is one of the most lethal human malignancies that currently has no effective therapy. We performed quantitative high-throughput screening (qHTS) in three ATC cell lines using 3,282 clinically approved drugs and drug candidates, and identified 100 active agents. Enrich...

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Detalles Bibliográficos
Autores principales: Zhang, Lisa, Zhang, Yaqin, Mehta, Amit, Boufraqech, Myriem, Davis, Sean, Wang, Jing, Tian, Ze, Yu, Zhiya, Boxer, Matthew B., Kiefer, Jeffrey A., Copland, John A., Smallridge, Robert C., Li, Zhuyin, Shen, Min, Kebebew, Electron
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4496203/
https://www.ncbi.nlm.nih.gov/pubmed/25940539

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