Overexpression of mutant Ptch in rhabdomyosarcomas is associated with promoter hypomethylation and increased Gli1 and H3K4me3 occupancy

Mice with heterozygous loss of the tumor suppressor Patched1 (Ptch) develop rhabdomyosarcoma (RMS)-like tumors. However, Ptch transcripts are consistently overexpressed in these tumors. We have recently shown that the upregulated transcripts are derived from the mutated Ptch allele thus leading to t...

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Detalles Bibliográficos
Autores principales: Nitzki, Frauke, Tolosa, Ezequiel J., Cuvelier, Nicole, Frommhold, Anke, Salinas-Riester, Gabriela, Johnsen, Steven A., Fernandez-Zapico, Martin E., Hahn, Heidi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4496206/
https://www.ncbi.nlm.nih.gov/pubmed/25823816

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