Podoplanin-expressing cancer-associated fibroblasts inhibit small cell lung cancer growth

Cancer-associated fibroblasts (CAFs) expressing podoplanin (PDPN) are a favorable prognosticator in surgically resected small cell lung cancer (SCLC). Here we explore whether CAFs expressing PDPN influence proliferation of SCLC cells. Compared with control group (SCLC cells co-cultured with CAFs-Ctr...

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Detalles Bibliográficos
Autores principales: Takahashi, Akiko, Ishii, Genichiro, Neri, Shinya, Yoshida, Tatsuya, Hashimoto, Hiroko, Suzuki, Shigeki, Umemura, Shigeki, Matsumoto, Shingo, Yoh, Kiyotaka, Niho, Seiji, Goto, Koichi, Ohmatsu, Hironobu, Nagai, Kanji, Gemma, Akihiko, Ohe, Yuichiro, Ochiai, Atsushi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4496236/
https://www.ncbi.nlm.nih.gov/pubmed/25909164
Descripción
Sumario:Cancer-associated fibroblasts (CAFs) expressing podoplanin (PDPN) are a favorable prognosticator in surgically resected small cell lung cancer (SCLC). Here we explore whether CAFs expressing PDPN influence proliferation of SCLC cells. Compared with control group (SCLC cells co-cultured with CAFs-Ctrl), numbers of SCLC cells co-cultured with CAFs overexpressing PDPN were decreased. Suppression of PDPN expression by shRNA in CAFs resulted in increased numbers of SCLC cells. In surgically resected human SCLC specimens, the frequency of Geminin-positive cancer cells was significantly higher in the cases with PDPN-positive CAFs than in the cases with PDPN-negative CAFs. Thus CAFs expressing PDPN inhibit growth of SCLC cells, suggesting that CAFs expressing PDPN represent a tumor inhibitory stromal cell component in SCLC.

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