MPGES-1-derived PGE2 suppresses CD80 expression on tumor-associated phagocytes to inhibit anti-tumor immune responses in breast cancer

Prostaglandin E(2) (PGE(2)) favors multiple aspects of tumor development and immune evasion. Therefore, microsomal prostaglandin E synthase (mPGES-1/-2), is a potential target for cancer therapy. We explored whether inhibiting mPGES-1 in human and mouse models of breast cancer affects tumor-associat...

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Detalles Bibliográficos
Autores principales: Olesch, Catherine, Sha, Weixiao, Angioni, Carlo, Sha, Lisa Katharina, Açaf, Elias, Patrignani, Paola, Jakobsson, Per-Johan, Radeke, Heinfried H., Grösch, Sabine, Geisslinger, Gerd, von Knethen, Andreas, Weigert, Andreas, Brüne, Bernhard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4496355/
https://www.ncbi.nlm.nih.gov/pubmed/25871398

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