Dysregulation of the miR-34a-SIRT1 axis inhibits breast cancer stemness

Enforced expression of miR-34a eliminates cancer stem cells in some malignant tumors. Sirtuin-1 (SIRT1) is a direct target of miR-34a. Here we found low levels of miR-34a and high levels of SIRT1 in CD44+/CD24− breast cancer stem cells (BCSCs). MiR-34a overexpression and knockdown of SIRT1 decreased...

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Detalles Bibliográficos
Autores principales: Ma, Wei, Xiao, Gary Guishan, Mao, Jun, Lu, Ying, Song, Bo, Wang, Lihui, Fan, Shujun, Fan, Panhong, Hou, Zhenhuan, Li, Jiazhi, Yu, Xiaotang, Wang, Bo, Wang, Huan, Wang, Honghai, Xu, Fei, Li, Yan, Liu, Qiang, Li, Lianhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4496365/
https://www.ncbi.nlm.nih.gov/pubmed/25826085

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