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Loss of Cbl and Cbl-b ubiquitin ligases abrogates hematopoietic stem cell quiescence and sensitizes leukemic disease to chemotherapy

Cbl and Cbl-b are tyrosine kinase-directed RING finger type ubiquitin ligases (E3s) that negatively regulate cellular activation pathways. E3 activity-disrupting human Cbl mutations are associated with myeloproliferative disorders (MPD) that are reproduced in mice with Cbl RING finger mutant knock-i...

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Detalles Bibliográficos
Autores principales:	An, Wei, Nadeau, Scott A., Mohapatra, Bhopal C., Feng, Dan, Zutshi, Neha, Storck, Matthew D., Arya, Priyanka, Talmadge, James E., Meza, Jane L., Band, Vimla, Band, Hamid
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2015
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4496370/ https://www.ncbi.nlm.nih.gov/pubmed/25871390

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