Cargando…
Polypharmacology of small molecules targeting the ubiquitin–proteasome and ubiquitin-like systems
Targeting the ubiquitin–proteasome system (UPS) and ubiquitin-like signalling systems (UBL) has been considered a promising therapeutic strategy to treat cancer, neurodegenerative and immunological disorders. There have been multiple efforts recently to identify novel compounds that efficiently modu...
Autores principales: | Amelio, Ivano, Landré, Vivien, Knight, Richard A., Lisitsa, Andrey, Melino, Gerry, Antonov, Alexey V. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4496386/ https://www.ncbi.nlm.nih.gov/pubmed/25991664 |
Ejemplares similares
-
Screening for E3-Ubiquitin ligase inhibitors: challenges and opportunities
por: Landré, Vivien, et al.
Publicado: (2014) -
p73 promotes glioblastoma cell invasion by directly activating POSTN (periostin) expression
por: Landré, Vivien, et al.
Publicado: (2016) -
Targeting the Ubiquitin-Proteasome System for Cancer Therapeutics by Small-Molecule Inhibitors
por: LaPlante, Gabriel, et al.
Publicado: (2021) -
Ubiquitin-like protein conjugation and the ubiquitin–proteasome system as drug targets
por: Bedford, Lynn, et al.
Publicado: (2010) -
Patented small molecule inhibitors in the ubiquitin proteasome system
por: Guédat, Philippe, et al.
Publicado: (2007)