Circadian genes Per1 and Per2 increase radiosensitivity of glioma in vivo

Per1 and Per2 play a key role in regulating the circadian rhythm in mammals. We report here that although both genes were expressed with a circadian rhythm in glioma and normal brain tissue in rats, their expression profiles differed in the two types of tissue. In addition, high expression of Per1 a...

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Autores principales: Zhanfeng, Niu, Yanhui, Li, Zhou, Fei, Shaocai, Hao, Guangxing, Li, Hechun, Xia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4496409/
https://www.ncbi.nlm.nih.gov/pubmed/25760074
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author Zhanfeng, Niu
Yanhui, Li
Zhou, Fei
Shaocai, Hao
Guangxing, Li
Hechun, Xia
author_facet Zhanfeng, Niu
Yanhui, Li
Zhou, Fei
Shaocai, Hao
Guangxing, Li
Hechun, Xia
author_sort Zhanfeng, Niu
collection PubMed
description Per1 and Per2 play a key role in regulating the circadian rhythm in mammals. We report here that although both genes were expressed with a circadian rhythm in glioma and normal brain tissue in rats, their expression profiles differed in the two types of tissue. In addition, high expression of Per1 and Per2 in glioma tissue was associated with increased sensitivity to x-irradiation. No such sensitizing effect was observed in normal tissue. Our results suggest that Per1 and Per2 expression may increase the efficacy of radiotherapy against glioma by promoting apoptosis.
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spelling pubmed-44964092015-07-15 Circadian genes Per1 and Per2 increase radiosensitivity of glioma in vivo Zhanfeng, Niu Yanhui, Li Zhou, Fei Shaocai, Hao Guangxing, Li Hechun, Xia Oncotarget Research Paper Per1 and Per2 play a key role in regulating the circadian rhythm in mammals. We report here that although both genes were expressed with a circadian rhythm in glioma and normal brain tissue in rats, their expression profiles differed in the two types of tissue. In addition, high expression of Per1 and Per2 in glioma tissue was associated with increased sensitivity to x-irradiation. No such sensitizing effect was observed in normal tissue. Our results suggest that Per1 and Per2 expression may increase the efficacy of radiotherapy against glioma by promoting apoptosis. Impact Journals LLC 2015-02-07 /pmc/articles/PMC4496409/ /pubmed/25760074 Text en Copyright: © 2015 Zhanfeng et al. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
Zhanfeng, Niu
Yanhui, Li
Zhou, Fei
Shaocai, Hao
Guangxing, Li
Hechun, Xia
Circadian genes Per1 and Per2 increase radiosensitivity of glioma in vivo
title Circadian genes Per1 and Per2 increase radiosensitivity of glioma in vivo
title_full Circadian genes Per1 and Per2 increase radiosensitivity of glioma in vivo
title_fullStr Circadian genes Per1 and Per2 increase radiosensitivity of glioma in vivo
title_full_unstemmed Circadian genes Per1 and Per2 increase radiosensitivity of glioma in vivo
title_short Circadian genes Per1 and Per2 increase radiosensitivity of glioma in vivo
title_sort circadian genes per1 and per2 increase radiosensitivity of glioma in vivo
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4496409/
https://www.ncbi.nlm.nih.gov/pubmed/25760074
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