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CXCR6 expression in non-small cell lung carcinoma supports metastatic process via modulating metalloproteinases
Lung cancer (LuCa) is the leading cause of cancer-related deaths worldwide regardless of the gender. High mortality associated with LuCa is due to metastasis, molecular mechanisms of which are yet to be defined. Here, we present evidence that chemokine receptor CXCR6 and its only natural ligand, CXC...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4496412/ https://www.ncbi.nlm.nih.gov/pubmed/25888629 |
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author | Mir, Hina Singh, Rajesh Kloecker, Goetz H. Lillard, James W. Singh, Shailesh |
author_facet | Mir, Hina Singh, Rajesh Kloecker, Goetz H. Lillard, James W. Singh, Shailesh |
author_sort | Mir, Hina |
collection | PubMed |
description | Lung cancer (LuCa) is the leading cause of cancer-related deaths worldwide regardless of the gender. High mortality associated with LuCa is due to metastasis, molecular mechanisms of which are yet to be defined. Here, we present evidence that chemokine receptor CXCR6 and its only natural ligand, CXCL16, are significantly expressed by non-small cell lung cancer (NSCLC) and are involved in the pathobiology of LuCa. CXCR6 expression was significantly higher in two subtypes of NSCLC (adenocarcinomas-ACs and squamous cell carcinoma-SCCs) as compared to non-neoplastic tissue. Additionally, serum CXCL16 was significantly elevated in LuCa cases as compared to healthy controls. Similar to CXCR6 tissue expression, serum level of CXCL16 in AC patients was significantly higher than SCC patients. Biological significance of this axis was validated using SCC and AC cell lines. Expression of CXCR6 was higher in AC cells, which also showed higher migratory and invasive potential than SCC. Differences in migratory and invasive potential between AC and SCC were due to differential expression of metalloproteinases following CXCL16 stimulation. Hence, our findings suggest clinical and biological significance of CXCR6/CXCL16 axis in LuCa, which could be used as potential prognostic marker and therapeutic target. |
format | Online Article Text |
id | pubmed-4496412 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Impact Journals LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-44964122015-07-15 CXCR6 expression in non-small cell lung carcinoma supports metastatic process via modulating metalloproteinases Mir, Hina Singh, Rajesh Kloecker, Goetz H. Lillard, James W. Singh, Shailesh Oncotarget Research Paper Lung cancer (LuCa) is the leading cause of cancer-related deaths worldwide regardless of the gender. High mortality associated with LuCa is due to metastasis, molecular mechanisms of which are yet to be defined. Here, we present evidence that chemokine receptor CXCR6 and its only natural ligand, CXCL16, are significantly expressed by non-small cell lung cancer (NSCLC) and are involved in the pathobiology of LuCa. CXCR6 expression was significantly higher in two subtypes of NSCLC (adenocarcinomas-ACs and squamous cell carcinoma-SCCs) as compared to non-neoplastic tissue. Additionally, serum CXCL16 was significantly elevated in LuCa cases as compared to healthy controls. Similar to CXCR6 tissue expression, serum level of CXCL16 in AC patients was significantly higher than SCC patients. Biological significance of this axis was validated using SCC and AC cell lines. Expression of CXCR6 was higher in AC cells, which also showed higher migratory and invasive potential than SCC. Differences in migratory and invasive potential between AC and SCC were due to differential expression of metalloproteinases following CXCL16 stimulation. Hence, our findings suggest clinical and biological significance of CXCR6/CXCL16 axis in LuCa, which could be used as potential prognostic marker and therapeutic target. Impact Journals LLC 2015-04-07 /pmc/articles/PMC4496412/ /pubmed/25888629 Text en Copyright: © 2015 Mir et al. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Paper Mir, Hina Singh, Rajesh Kloecker, Goetz H. Lillard, James W. Singh, Shailesh CXCR6 expression in non-small cell lung carcinoma supports metastatic process via modulating metalloproteinases |
title | CXCR6 expression in non-small cell lung carcinoma supports metastatic process via modulating metalloproteinases |
title_full | CXCR6 expression in non-small cell lung carcinoma supports metastatic process via modulating metalloproteinases |
title_fullStr | CXCR6 expression in non-small cell lung carcinoma supports metastatic process via modulating metalloproteinases |
title_full_unstemmed | CXCR6 expression in non-small cell lung carcinoma supports metastatic process via modulating metalloproteinases |
title_short | CXCR6 expression in non-small cell lung carcinoma supports metastatic process via modulating metalloproteinases |
title_sort | cxcr6 expression in non-small cell lung carcinoma supports metastatic process via modulating metalloproteinases |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4496412/ https://www.ncbi.nlm.nih.gov/pubmed/25888629 |
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