Cargando…
Stabilisation of Laryngeal AL Amyloidosis with Long Term Curcumin Therapy
Multiple myeloma (MM), smoldering myeloma (SMM), and monoclonal gammopathy of undetermined significance (MGUS) represent a spectrum of plasma cell dyscrasias (PCDs). Immunoglobulin light chain amyloidosis (AL) falls within the spectrum of these diseases and has a mortality rate of more than 80% with...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4496470/ https://www.ncbi.nlm.nih.gov/pubmed/26199769 http://dx.doi.org/10.1155/2015/910528 |
_version_ | 1782380409656442880 |
---|---|
author | Golombick, Terry Diamond, Terrence H. Manoharan, Arumugam Ramakrishna, Rajeev |
author_facet | Golombick, Terry Diamond, Terrence H. Manoharan, Arumugam Ramakrishna, Rajeev |
author_sort | Golombick, Terry |
collection | PubMed |
description | Multiple myeloma (MM), smoldering myeloma (SMM), and monoclonal gammopathy of undetermined significance (MGUS) represent a spectrum of plasma cell dyscrasias (PCDs). Immunoglobulin light chain amyloidosis (AL) falls within the spectrum of these diseases and has a mortality rate of more than 80% within 2 years of diagnosis. Curcumin, derived from turmeric, has been shown to have a clinical benefit in some patients with PCDs. In addition to a clinical benefit in these patients, curcumin has been found to have a strong affinity for fibrillar amyloid proteins. We thus administered curcumin to a patient with laryngeal amyloidosis and smoldering myeloma and found that the patient has shown a lack of progression of his disease for a period of five years. This is in keeping with our previous findings of clinical benefits of curcumin in patients with plasma cell dyscrasias. We recommend further evaluation of curcumin in patients with primary AL amyloidosis. |
format | Online Article Text |
id | pubmed-4496470 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-44964702015-07-21 Stabilisation of Laryngeal AL Amyloidosis with Long Term Curcumin Therapy Golombick, Terry Diamond, Terrence H. Manoharan, Arumugam Ramakrishna, Rajeev Case Rep Hematol Case Report Multiple myeloma (MM), smoldering myeloma (SMM), and monoclonal gammopathy of undetermined significance (MGUS) represent a spectrum of plasma cell dyscrasias (PCDs). Immunoglobulin light chain amyloidosis (AL) falls within the spectrum of these diseases and has a mortality rate of more than 80% within 2 years of diagnosis. Curcumin, derived from turmeric, has been shown to have a clinical benefit in some patients with PCDs. In addition to a clinical benefit in these patients, curcumin has been found to have a strong affinity for fibrillar amyloid proteins. We thus administered curcumin to a patient with laryngeal amyloidosis and smoldering myeloma and found that the patient has shown a lack of progression of his disease for a period of five years. This is in keeping with our previous findings of clinical benefits of curcumin in patients with plasma cell dyscrasias. We recommend further evaluation of curcumin in patients with primary AL amyloidosis. Hindawi Publishing Corporation 2015 2015-06-25 /pmc/articles/PMC4496470/ /pubmed/26199769 http://dx.doi.org/10.1155/2015/910528 Text en Copyright © 2015 Terry Golombick et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Golombick, Terry Diamond, Terrence H. Manoharan, Arumugam Ramakrishna, Rajeev Stabilisation of Laryngeal AL Amyloidosis with Long Term Curcumin Therapy |
title | Stabilisation of Laryngeal AL Amyloidosis with Long Term Curcumin Therapy |
title_full | Stabilisation of Laryngeal AL Amyloidosis with Long Term Curcumin Therapy |
title_fullStr | Stabilisation of Laryngeal AL Amyloidosis with Long Term Curcumin Therapy |
title_full_unstemmed | Stabilisation of Laryngeal AL Amyloidosis with Long Term Curcumin Therapy |
title_short | Stabilisation of Laryngeal AL Amyloidosis with Long Term Curcumin Therapy |
title_sort | stabilisation of laryngeal al amyloidosis with long term curcumin therapy |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4496470/ https://www.ncbi.nlm.nih.gov/pubmed/26199769 http://dx.doi.org/10.1155/2015/910528 |
work_keys_str_mv | AT golombickterry stabilisationoflaryngealalamyloidosiswithlongtermcurcumintherapy AT diamondterrenceh stabilisationoflaryngealalamyloidosiswithlongtermcurcumintherapy AT manoharanarumugam stabilisationoflaryngealalamyloidosiswithlongtermcurcumintherapy AT ramakrishnarajeev stabilisationoflaryngealalamyloidosiswithlongtermcurcumintherapy |