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DNA-dependent targeting of cell nuclei by a lupus autoantibody

A nuclear-penetrating lupus anti-DNA autoantibody, 3E10, has been found to inhibit DNA repair and selectively kill certain cancer cells that are highly vulnerable to DNA damage. In addition, a 3E10 single chain variable fragment (scFv) has been developed for use as a delivery vehicle to carry therap...

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Detalles Bibliográficos
Autores principales:	Weisbart, Richard H., Chan, Grace, Jordaan, Gwen, Noble, Philip W., Liu, Yanfeng, Glazer, Peter M., Nishimura, Robert N., Hansen, James E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4496662/ https://www.ncbi.nlm.nih.gov/pubmed/26156563 http://dx.doi.org/10.1038/srep12022

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