Heme Degradation by Heme Oxygenase Protects Mitochondria but Induces ER Stress via Formed Bilirubin

Heme oxygenase (HO), in conjunction with biliverdin reductase, degrades heme to carbon monoxide, ferrous iron and bilirubin (BR); the latter is a potent antioxidant. The induced isoform HO-1 has evoked intense research interest, especially because it manifests anti-inflammatory and anti-apoptotic ef...

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Detalles Bibliográficos
Autores principales: Müllebner, Andrea, Moldzio, Rudolf, Redl, Heinz, Kozlov, Andrey V., Duvigneau, J. Catharina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4496691/
https://www.ncbi.nlm.nih.gov/pubmed/25942605
http://dx.doi.org/10.3390/biom5020679

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