Study of cardiovascular disease biomarkers among tobacco consumers, part 2: biomarkers of biological effect

An age-stratified, cross-sectional study was conducted in the US among healthy adult male cigarette smokers, moist snuff consumers, and non-tobacco consumers to evaluate cardiovascular biomarkers of biological effect (BoBE). Physiological assessments included flow-mediated dilation, ankle-brachial i...

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Detalles Bibliográficos
Autores principales: Nordskog, Brian K., Brown, Buddy G., Marano, Kristin M., Campell, Leanne R., Jones, Bobbette A., Borgerding, Michael F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Informa Healthcare 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4496813/
https://www.ncbi.nlm.nih.gov/pubmed/25787701
http://dx.doi.org/10.3109/08958378.2015.1013227
Descripción
Sumario:An age-stratified, cross-sectional study was conducted in the US among healthy adult male cigarette smokers, moist snuff consumers, and non-tobacco consumers to evaluate cardiovascular biomarkers of biological effect (BoBE). Physiological assessments included flow-mediated dilation, ankle-brachial index, carotid intima-media thickness and expired carbon monoxide. Approximately one-half of the measured serum BoBE showed statistically significant differences; IL-12(p70), sICAM-1 and IL-8 were the BoBE that best differentiated among the three groups. A significant difference in ABI was observed between the cigarette smokers and non-tobacco consumer groups. Significant group and age effect differences in select biomarkers were identified.

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