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The combination of intravenous Reolysin and gemcitabine induces reovirus replication and endoplasmic reticular stress in a patient with KRAS-activated pancreatic cancer

BACKGROUND: Activating mutations in RAS are present in the majority of pancreatic cancer cases and represent an ideal therapeutic target. Reolysin is a proprietary formulation of oncolytic reovirus that is currently being evaluated in multiple clinical trials due to its ability to selectively replic...

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Detalles Bibliográficos
Autores principales:	Mahalingam, Devalingam, Patel, Sukeshi, Nuovo, Gerard, Gill, George, Selvaggi, Giovanni, Coffey, Matt, Nawrocki, Steffan T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Case Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4496814/ https://www.ncbi.nlm.nih.gov/pubmed/26156229 http://dx.doi.org/10.1186/s12885-015-1518-0

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