Arteriovenous malformation within an isocitrate dehydrogenase 1 mutated anaplastic oligodendroglioma

BACKGROUND: The co-occurrence of intracranial arteriovenous malformations (AVMs) and cerebral neoplasms is exceedingly rare but may harbor implications pertaining to the molecular medicine of brain cancer pathogenesis. CASE DESCRIPTION: Here, we present a case of de novo AVM within an isocitrate deh...

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Detalles Bibliográficos
Autores principales: Lai, Grace, Muller, Karra A., Carter, Bob S., Chen, Clark C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2015
Materias:
Surgical Neurology International: Unique Case Observations
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4496836/
https://www.ncbi.nlm.nih.gov/pubmed/26167373
http://dx.doi.org/10.4103/2152-7806.159373
Descripción
Sumario:BACKGROUND: The co-occurrence of intracranial arteriovenous malformations (AVMs) and cerebral neoplasms is exceedingly rare but may harbor implications pertaining to the molecular medicine of brain cancer pathogenesis. CASE DESCRIPTION: Here, we present a case of de novo AVM within an isocitrate dehydrogenase 1 mutated anaplastic oligodendroglioma (WHO Grade III) and review the potential contribution of this mutation to aberrant angiogenesis as an interesting case study in molecular medicine. CONCLUSION: The co-occurrence of an IDH1 mutated neoplasm and AVM supports the hypothesis that IDH1 mutations may contribute to aberrant angiogenesis and vascular malformation.

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