Arteriovenous malformation within an isocitrate dehydrogenase 1 mutated anaplastic oligodendroglioma

BACKGROUND: The co-occurrence of intracranial arteriovenous malformations (AVMs) and cerebral neoplasms is exceedingly rare but may harbor implications pertaining to the molecular medicine of brain cancer pathogenesis. CASE DESCRIPTION: Here, we present a case of de novo AVM within an isocitrate deh...

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Detalles Bibliográficos
Autores principales: Lai, Grace, Muller, Karra A., Carter, Bob S., Chen, Clark C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2015
Materias:
Surgical Neurology International: Unique Case Observations
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4496836/
https://www.ncbi.nlm.nih.gov/pubmed/26167373
http://dx.doi.org/10.4103/2152-7806.159373
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author Lai, Grace
Muller, Karra A.
Carter, Bob S.
Chen, Clark C.
author_facet Lai, Grace
Muller, Karra A.
Carter, Bob S.
Chen, Clark C.
author_sort Lai, Grace
collection PubMed
description BACKGROUND: The co-occurrence of intracranial arteriovenous malformations (AVMs) and cerebral neoplasms is exceedingly rare but may harbor implications pertaining to the molecular medicine of brain cancer pathogenesis. CASE DESCRIPTION: Here, we present a case of de novo AVM within an isocitrate dehydrogenase 1 mutated anaplastic oligodendroglioma (WHO Grade III) and review the potential contribution of this mutation to aberrant angiogenesis as an interesting case study in molecular medicine. CONCLUSION: The co-occurrence of an IDH1 mutated neoplasm and AVM supports the hypothesis that IDH1 mutations may contribute to aberrant angiogenesis and vascular malformation.
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spelling pubmed-44968362015-07-12 Arteriovenous malformation within an isocitrate dehydrogenase 1 mutated anaplastic oligodendroglioma Lai, Grace Muller, Karra A. Carter, Bob S. Chen, Clark C. Surg Neurol Int Surgical Neurology International: Unique Case Observations BACKGROUND: The co-occurrence of intracranial arteriovenous malformations (AVMs) and cerebral neoplasms is exceedingly rare but may harbor implications pertaining to the molecular medicine of brain cancer pathogenesis. CASE DESCRIPTION: Here, we present a case of de novo AVM within an isocitrate dehydrogenase 1 mutated anaplastic oligodendroglioma (WHO Grade III) and review the potential contribution of this mutation to aberrant angiogenesis as an interesting case study in molecular medicine. CONCLUSION: The co-occurrence of an IDH1 mutated neoplasm and AVM supports the hypothesis that IDH1 mutations may contribute to aberrant angiogenesis and vascular malformation. Medknow Publications & Media Pvt Ltd 2015-06-25 /pmc/articles/PMC4496836/ /pubmed/26167373 http://dx.doi.org/10.4103/2152-7806.159373 Text en Copyright: © 2015 Lai G. http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Surgical Neurology International: Unique Case Observations
Lai, Grace
Muller, Karra A.
Carter, Bob S.
Chen, Clark C.
Arteriovenous malformation within an isocitrate dehydrogenase 1 mutated anaplastic oligodendroglioma
title Arteriovenous malformation within an isocitrate dehydrogenase 1 mutated anaplastic oligodendroglioma
title_full Arteriovenous malformation within an isocitrate dehydrogenase 1 mutated anaplastic oligodendroglioma
title_fullStr Arteriovenous malformation within an isocitrate dehydrogenase 1 mutated anaplastic oligodendroglioma
title_full_unstemmed Arteriovenous malformation within an isocitrate dehydrogenase 1 mutated anaplastic oligodendroglioma
title_short Arteriovenous malformation within an isocitrate dehydrogenase 1 mutated anaplastic oligodendroglioma
title_sort arteriovenous malformation within an isocitrate dehydrogenase 1 mutated anaplastic oligodendroglioma
topic Surgical Neurology International: Unique Case Observations
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4496836/
https://www.ncbi.nlm.nih.gov/pubmed/26167373
http://dx.doi.org/10.4103/2152-7806.159373
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AT carterbobs arteriovenousmalformationwithinanisocitratedehydrogenase1mutatedanaplasticoligodendroglioma
AT chenclarkc arteriovenousmalformationwithinanisocitratedehydrogenase1mutatedanaplasticoligodendroglioma

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