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Probing Reversible Chemistry in Coenzyme B(12)-Dependent Ethanolamine Ammonia Lyase with Kinetic Isotope Effects

Coenzyme B(12)-dependent enzymes such as ethanolamine ammonia lyase have remarkable catalytic power and some unique properties that enable detailed analysis of the reaction chemistry and associated dynamics. By selectively deuterating the substrate (ethanolamine) and/or the β-carbon of the 5′-deoxya...

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Detalles Bibliográficos
Autores principales:	Jones, Alex R, Rentergent, Julius, Scrutton, Nigel S, Hay, Sam
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	WILEY-VCH Verlag 2015
Materias:	Full Papers
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4497352/ https://www.ncbi.nlm.nih.gov/pubmed/25950663 http://dx.doi.org/10.1002/chem.201500958

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