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A surveillance study of intensity-modulated radiation therapy for postoperative cervical cancer in Japan
Intensity-modulated radiation therapy (IMRT) was recently introduced to the field of gynecologic malignancies; however, its value is not yet validated. A clinical trial is in preparation to investigate the efficacy and feasibility of IMRT for postoperative cervical cancer. The object of this study w...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4497393/ https://www.ncbi.nlm.nih.gov/pubmed/25862699 http://dx.doi.org/10.1093/jrr/rrv020 |
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author | Murakami, Naoya Okamoto, Hiroyuki Isohashi, Fumiaki Murofushi, Keiko Ohno, Tatsuya Yoshida, Daisaku Saito, Makoto Inaba, Koji Ito, Yoshinori Toita, Takafumi Itami, Jun |
author_facet | Murakami, Naoya Okamoto, Hiroyuki Isohashi, Fumiaki Murofushi, Keiko Ohno, Tatsuya Yoshida, Daisaku Saito, Makoto Inaba, Koji Ito, Yoshinori Toita, Takafumi Itami, Jun |
author_sort | Murakami, Naoya |
collection | PubMed |
description | Intensity-modulated radiation therapy (IMRT) was recently introduced to the field of gynecologic malignancies; however, its value is not yet validated. A clinical trial is in preparation to investigate the efficacy and feasibility of IMRT for postoperative cervical cancer. The object of this study was to perform a surveillance study of IMRT for post-operative cervical cancer. A questionnaire regarding the precise methods of conducting IMRT was sent to six institutions that had already introduced IMRT for post-operative cervical cancer, and the data were analyzed. Half of the institutions used static IMRT and the others used volumetric-modulated arc therapy (VMAT). Most institutions used body-immobilizing devices for patient fixation. Most institutions instructed patients to fill their bladder before undergoing planning CT or daily treatment. While one institution inserted metallic markers and another one used radio-contrast–soaked gauze to visualize the vaginal cuff, the other institutions used nothing for vaginal cuff visualization. Most institutions defined the clinical target volumes according to the Japan Clinical Oncology Group or the Radiation Therapy Oncology Group guidelines. Only one institution used a prescribed dose based on 95% of the PTV (D(95)), while the rest used the mean dose (D(mean)). This valuable information from six leading institutions will be utilized in a future prospective clinical trial. |
format | Online Article Text |
id | pubmed-4497393 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-44973932015-07-10 A surveillance study of intensity-modulated radiation therapy for postoperative cervical cancer in Japan Murakami, Naoya Okamoto, Hiroyuki Isohashi, Fumiaki Murofushi, Keiko Ohno, Tatsuya Yoshida, Daisaku Saito, Makoto Inaba, Koji Ito, Yoshinori Toita, Takafumi Itami, Jun J Radiat Res Oncology Intensity-modulated radiation therapy (IMRT) was recently introduced to the field of gynecologic malignancies; however, its value is not yet validated. A clinical trial is in preparation to investigate the efficacy and feasibility of IMRT for postoperative cervical cancer. The object of this study was to perform a surveillance study of IMRT for post-operative cervical cancer. A questionnaire regarding the precise methods of conducting IMRT was sent to six institutions that had already introduced IMRT for post-operative cervical cancer, and the data were analyzed. Half of the institutions used static IMRT and the others used volumetric-modulated arc therapy (VMAT). Most institutions used body-immobilizing devices for patient fixation. Most institutions instructed patients to fill their bladder before undergoing planning CT or daily treatment. While one institution inserted metallic markers and another one used radio-contrast–soaked gauze to visualize the vaginal cuff, the other institutions used nothing for vaginal cuff visualization. Most institutions defined the clinical target volumes according to the Japan Clinical Oncology Group or the Radiation Therapy Oncology Group guidelines. Only one institution used a prescribed dose based on 95% of the PTV (D(95)), while the rest used the mean dose (D(mean)). This valuable information from six leading institutions will be utilized in a future prospective clinical trial. Oxford University Press 2015-07 2015-04-09 /pmc/articles/PMC4497393/ /pubmed/25862699 http://dx.doi.org/10.1093/jrr/rrv020 Text en © The Author 2015. Published by Oxford University Press on behalf of The Japan Radiation Research Society and Japanese Society for Radiation Oncology. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com |
spellingShingle | Oncology Murakami, Naoya Okamoto, Hiroyuki Isohashi, Fumiaki Murofushi, Keiko Ohno, Tatsuya Yoshida, Daisaku Saito, Makoto Inaba, Koji Ito, Yoshinori Toita, Takafumi Itami, Jun A surveillance study of intensity-modulated radiation therapy for postoperative cervical cancer in Japan |
title | A surveillance study of intensity-modulated radiation therapy for postoperative cervical cancer in Japan |
title_full | A surveillance study of intensity-modulated radiation therapy for postoperative cervical cancer in Japan |
title_fullStr | A surveillance study of intensity-modulated radiation therapy for postoperative cervical cancer in Japan |
title_full_unstemmed | A surveillance study of intensity-modulated radiation therapy for postoperative cervical cancer in Japan |
title_short | A surveillance study of intensity-modulated radiation therapy for postoperative cervical cancer in Japan |
title_sort | surveillance study of intensity-modulated radiation therapy for postoperative cervical cancer in japan |
topic | Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4497393/ https://www.ncbi.nlm.nih.gov/pubmed/25862699 http://dx.doi.org/10.1093/jrr/rrv020 |
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