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Structure and functional properties of Norrin mimic Wnt for signalling with Frizzled4, Lrp5/6, and proteoglycan

Wnt signalling regulates multiple processes including angiogenesis, inflammation, and tumorigenesis. Norrin (Norrie Disease Protein) is a cystine-knot like growth factor. Although unrelated to Wnt, Norrin activates the Wnt/β-catenin pathway. Signal complex formation involves Frizzled4 (Fz4), low-den...

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Detalles Bibliográficos
Autores principales:	Chang, Tao-Hsin, Hsieh, Fu-Lien, Zebisch, Matthias, Harlos, Karl, Elegheert, Jonathan, Jones, E Yvonne
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2015
Materias:	Biophysics and Structural Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4497409/ https://www.ncbi.nlm.nih.gov/pubmed/26158506 http://dx.doi.org/10.7554/eLife.06554

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