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Molecular Design of Antifouling Polymer Brushes Using Sequence-Specific Peptoids

Material systems that can be used to flexibly and precisely define the chemical nature and molecular arrangement of a surface would be invaluable for the control of complex biointerfacial interactions. For example, progress in antifouling polymer biointerfaces that prevents nonspecific protein adsor...

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Autores principales: Lau, King Hang Aaron, Sileika, Tadas S, Park, Sung Hyun, Sousa, Ana ML, Burch, Patrick, Szleifer, Igal, Messersmith, Phillip B
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Ltd 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4497591/
https://www.ncbi.nlm.nih.gov/pubmed/26167449
http://dx.doi.org/10.1002/admi.201400225
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author Lau, King Hang Aaron
Sileika, Tadas S
Park, Sung Hyun
Sousa, Ana ML
Burch, Patrick
Szleifer, Igal
Messersmith, Phillip B
author_facet Lau, King Hang Aaron
Sileika, Tadas S
Park, Sung Hyun
Sousa, Ana ML
Burch, Patrick
Szleifer, Igal
Messersmith, Phillip B
author_sort Lau, King Hang Aaron
collection PubMed
description Material systems that can be used to flexibly and precisely define the chemical nature and molecular arrangement of a surface would be invaluable for the control of complex biointerfacial interactions. For example, progress in antifouling polymer biointerfaces that prevents nonspecific protein adsorption and cell attachment, which can significantly improve the performance of an array of biomedical and industrial applications, is hampered by a lack of chemical models to identify the molecular features conferring their properties. Poly(N-substituted glycine) “peptoids” are peptidomimetic polymers that can be conveniently synthesized with specific monomer sequences and chain lengths, and are presented as a versatile platform for investigating the molecular design of antifouling polymer brushes. Zwitterionic antifouling polymer brushes have captured significant recent attention, and a targeted library of zwitterionic peptoid brushes with different charge densities, hydration, separations between charged groups, chain lengths, and grafted chain densities, is quantitatively evaluated for their antifouling properties through a range of protein adsorption and cell attachment assays. Specific zwitterionic brush designs are found to give rise to distinct but subtle differences in properties. The results also point to the dominant roles of the grafted chain density and chain length in determining the performance of antifouling polymer brushes.
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spelling pubmed-44975912015-12-04 Molecular Design of Antifouling Polymer Brushes Using Sequence-Specific Peptoids Lau, King Hang Aaron Sileika, Tadas S Park, Sung Hyun Sousa, Ana ML Burch, Patrick Szleifer, Igal Messersmith, Phillip B Adv Mater Interfaces Full Papers Material systems that can be used to flexibly and precisely define the chemical nature and molecular arrangement of a surface would be invaluable for the control of complex biointerfacial interactions. For example, progress in antifouling polymer biointerfaces that prevents nonspecific protein adsorption and cell attachment, which can significantly improve the performance of an array of biomedical and industrial applications, is hampered by a lack of chemical models to identify the molecular features conferring their properties. Poly(N-substituted glycine) “peptoids” are peptidomimetic polymers that can be conveniently synthesized with specific monomer sequences and chain lengths, and are presented as a versatile platform for investigating the molecular design of antifouling polymer brushes. Zwitterionic antifouling polymer brushes have captured significant recent attention, and a targeted library of zwitterionic peptoid brushes with different charge densities, hydration, separations between charged groups, chain lengths, and grafted chain densities, is quantitatively evaluated for their antifouling properties through a range of protein adsorption and cell attachment assays. Specific zwitterionic brush designs are found to give rise to distinct but subtle differences in properties. The results also point to the dominant roles of the grafted chain density and chain length in determining the performance of antifouling polymer brushes. John Wiley & Sons, Ltd 2015-01-07 2014-11-26 /pmc/articles/PMC4497591/ /pubmed/26167449 http://dx.doi.org/10.1002/admi.201400225 Text en © 2014 The Authors. Published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim http://creativecommons.org/licenses/by-nc/4.0/ This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Full Papers
Lau, King Hang Aaron
Sileika, Tadas S
Park, Sung Hyun
Sousa, Ana ML
Burch, Patrick
Szleifer, Igal
Messersmith, Phillip B
Molecular Design of Antifouling Polymer Brushes Using Sequence-Specific Peptoids
title Molecular Design of Antifouling Polymer Brushes Using Sequence-Specific Peptoids
title_full Molecular Design of Antifouling Polymer Brushes Using Sequence-Specific Peptoids
title_fullStr Molecular Design of Antifouling Polymer Brushes Using Sequence-Specific Peptoids
title_full_unstemmed Molecular Design of Antifouling Polymer Brushes Using Sequence-Specific Peptoids
title_short Molecular Design of Antifouling Polymer Brushes Using Sequence-Specific Peptoids
title_sort molecular design of antifouling polymer brushes using sequence-specific peptoids
topic Full Papers
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4497591/
https://www.ncbi.nlm.nih.gov/pubmed/26167449
http://dx.doi.org/10.1002/admi.201400225
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