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Regulation and roles of Ca(2+) stores in human sperm
[Ca(2) (+)](i) signalling is a key regulatory mechanism in sperm function. In mammalian sperm the Ca(2) (+)-permeable plasma membrane ion channel CatSper is central to [Ca(2) (+)](i) signalling, but there is good evidence that Ca(2) (+) stored in intracellular organelles is also functionally importa...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Bioscientifica Ltd
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4497595/ https://www.ncbi.nlm.nih.gov/pubmed/25964382 http://dx.doi.org/10.1530/REP-15-0102 |
Sumario: | [Ca(2) (+)](i) signalling is a key regulatory mechanism in sperm function. In mammalian sperm the Ca(2) (+)-permeable plasma membrane ion channel CatSper is central to [Ca(2) (+)](i) signalling, but there is good evidence that Ca(2) (+) stored in intracellular organelles is also functionally important. Here we briefly review the current understanding of the diversity of Ca(2) (+) stores and the mechanisms for the regulation of their activity. We then consider the evidence for the involvement of these stores in [Ca(2) (+)](i) signalling in mammalian (primarily human) sperm, the agonists that may activate these stores and their role in control of sperm function. Finally we consider the evidence that membrane Ca(2) (+) channels and stored Ca(2) (+) may play discrete roles in the regulation of sperm activities and propose a mechanism by which these different components of the sperm Ca(2) (+)-signalling apparatus may interact to generate complex and spatially diverse [Ca(2) (+)](i) signals. |
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