Oxygenase-Catalyzed Desymmetrization of N,N-Dialkyl-piperidine-4-carboxylic Acids**

γ-Butyrobetaine hydroxylase (BBOX) is a 2-oxoglutarate dependent oxygenase that catalyzes the final hydroxylation step in the biosynthesis of carnitine. BBOX was shown to catalyze the oxidative desymmetrization of achiral N,N-dialkyl piperidine-4-carboxylates to give products with two or three stere...

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Detalles Bibliográficos
Autores principales: Rydzik, Anna M, Leung, Ivanhoe K H, Kochan, Grazyna T, McDonough, Michael A, Claridge, Timothy D W, Schofield, Christopher J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: WILEY-VCH Verlag 2014
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4497603/
https://www.ncbi.nlm.nih.gov/pubmed/25164544
http://dx.doi.org/10.1002/anie.201406125
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author Rydzik, Anna M
Leung, Ivanhoe K H
Kochan, Grazyna T
McDonough, Michael A
Claridge, Timothy D W
Schofield, Christopher J
author_facet Rydzik, Anna M
Leung, Ivanhoe K H
Kochan, Grazyna T
McDonough, Michael A
Claridge, Timothy D W
Schofield, Christopher J
author_sort Rydzik, Anna M
collection PubMed
description γ-Butyrobetaine hydroxylase (BBOX) is a 2-oxoglutarate dependent oxygenase that catalyzes the final hydroxylation step in the biosynthesis of carnitine. BBOX was shown to catalyze the oxidative desymmetrization of achiral N,N-dialkyl piperidine-4-carboxylates to give products with two or three stereogenic centers.
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spelling pubmed-44976032015-07-10 Oxygenase-Catalyzed Desymmetrization of N,N-Dialkyl-piperidine-4-carboxylic Acids** Rydzik, Anna M Leung, Ivanhoe K H Kochan, Grazyna T McDonough, Michael A Claridge, Timothy D W Schofield, Christopher J Angew Chem Int Ed Engl Communications γ-Butyrobetaine hydroxylase (BBOX) is a 2-oxoglutarate dependent oxygenase that catalyzes the final hydroxylation step in the biosynthesis of carnitine. BBOX was shown to catalyze the oxidative desymmetrization of achiral N,N-dialkyl piperidine-4-carboxylates to give products with two or three stereogenic centers. WILEY-VCH Verlag 2014-10-06 2014-08-27 /pmc/articles/PMC4497603/ /pubmed/25164544 http://dx.doi.org/10.1002/anie.201406125 Text en © 2014 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA. http://creativecommons.org/licenses/by/3.0/ This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited
spellingShingle Communications
Rydzik, Anna M
Leung, Ivanhoe K H
Kochan, Grazyna T
McDonough, Michael A
Claridge, Timothy D W
Schofield, Christopher J
Oxygenase-Catalyzed Desymmetrization of N,N-Dialkyl-piperidine-4-carboxylic Acids**
title Oxygenase-Catalyzed Desymmetrization of N,N-Dialkyl-piperidine-4-carboxylic Acids**
title_full Oxygenase-Catalyzed Desymmetrization of N,N-Dialkyl-piperidine-4-carboxylic Acids**
title_fullStr Oxygenase-Catalyzed Desymmetrization of N,N-Dialkyl-piperidine-4-carboxylic Acids**
title_full_unstemmed Oxygenase-Catalyzed Desymmetrization of N,N-Dialkyl-piperidine-4-carboxylic Acids**
title_short Oxygenase-Catalyzed Desymmetrization of N,N-Dialkyl-piperidine-4-carboxylic Acids**
title_sort oxygenase-catalyzed desymmetrization of n,n-dialkyl-piperidine-4-carboxylic acids**
topic Communications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4497603/
https://www.ncbi.nlm.nih.gov/pubmed/25164544
http://dx.doi.org/10.1002/anie.201406125
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