Cargando…

Oxygenase-Catalyzed Desymmetrization of N,N-Dialkyl-piperidine-4-carboxylic Acids**

γ-Butyrobetaine hydroxylase (BBOX) is a 2-oxoglutarate dependent oxygenase that catalyzes the final hydroxylation step in the biosynthesis of carnitine. BBOX was shown to catalyze the oxidative desymmetrization of achiral N,N-dialkyl piperidine-4-carboxylates to give products with two or three stere...

Descripción completa

Detalles Bibliográficos
Autores principales:	Rydzik, Anna M, Leung, Ivanhoe K H, Kochan, Grazyna T, McDonough, Michael A, Claridge, Timothy D W, Schofield, Christopher J
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	WILEY-VCH Verlag 2014
Materias:	Communications
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4497603/ https://www.ncbi.nlm.nih.gov/pubmed/25164544 http://dx.doi.org/10.1002/anie.201406125

Ejemplares similares

Non-enzymatic chemistry enables 2-hydroxyglutarate-mediated activation of 2-oxoglutarate oxygenases
por: Tarhonskaya, Hanna, et al.
Publicado: (2014)

Identifying the true origins of selectivity in chiral phosphoric acid catalyzed N-acyl-azetidine desymmetrizations
por: Champagne, Pier Alexandre
Publicado: (2021)

Highly chemoselective ruthenium(ii)-catalyzed direct arylation of cyclic and N,N-dialkyl benzamides with aryl silanes
por: Nareddy, Pradeep, et al.
Publicado: (2017)

Phosphazene-catalyzed desymmetrization of cyclohexadienones by dithiane addition
por: Horwitz, Matthew A, et al.
Publicado: (2017)

Copper-Catalyzed Asymmetric Sulfonylative Desymmetrization of Glycerol
por: Yamamoto, Kosuke, et al.
Publicado: (2022)

Enantioselective synthesis of bicyclo[3.n.1]alkanes by chiral phosphoric acid-catalyzed desymmetrizing Michael cyclizations
por: Burns, Alan R., et al.
Publicado: (2015)

Chemodivergence in Pd-catalyzed desymmetrization of allenes: enantioselective [4+3] cycloaddition, desymmetric allenylic substitution and enynylation
por: Luo, Pengfei, et al.
Publicado: (2023)

Desymmetrization of Dicationic Diboranes by Isomerization Catalyzed by a Nucleophile
por: Schön, Florian, et al.
Publicado: (2020)

Desymmetrization of N-Cbz glutarimides through N-heterocyclic carbene organocatalysis
por: Hu, Zhouli, et al.
Publicado: (2022)

Novel N,N-dialkyl cyanocinnamic acids as monocarboxylate transporter 1 and 4 inhibitors
por: Jonnalagadda, Shirisha, et al.
Publicado: (2019)

AcsD catalyzes enantioselective citrate desymmetrization in siderophore biosynthesis
por: Schmelz, Stefan, et al.
Publicado: (2009)

Rh-catalyzed desymmetrization of α-quaternary centers by isomerization-hydroacylation
por: Park, Jung-Woo, et al.
Publicado: (2015)

Cobalt-catalyzed enantioselective desymmetrizing reductive cyclization of alkynyl cyclodiketones
por: Liang, Ren-Xiao, et al.
Publicado: (2023)

Computational Investigation on the Origin of Atroposelectivity for the Cinchona Alkaloid Primary Amine-Catalyzed Vinylogous Desymmetrization of N-(2-t-Butylphenyl)maleimides
por: Tampellini, Nicolò, et al.
Publicado: (2021)

Lithium BINOL Phosphate Catalyzed Desymmetrization of meso-Epoxides with Aromatic Thiols
por: Ingle, Gajendrasingh, et al.
Publicado: (2014)

Selenide-catalyzed enantioselective synthesis of trifluoromethylthiolated tetrahydronaphthalenes by merging desymmetrization and trifluoromethylthiolation
por: Luo, Jie, et al.
Publicado: (2018)

Directed nickel-catalyzed 1,2-dialkylation of alkenyl carbonyl compounds
por: Derosa, Joseph, et al.
Publicado: (2018)

Phenyl piperidine-1-carboxylate
por: Shahwar, Durre, et al.
Publicado: (2009)

Synthesis and Properties of N-Bromosuccinimide Derivatives of Ammonium Dialkyl/Alkylene Dithiophosphates
por: Harkut, Neelam, et al.
Publicado: (2007)

Iterative addition of carbon nucleophiles to N,N-dialkyl carboxamides for synthesis of α-tertiary amines
por: Chen, Jiahua, et al.
Publicado: (2021)

Protein Hydroxylation Catalyzed by 2-Oxoglutarate-dependent Oxygenases
por: Markolovic, Suzana, et al.
Publicado: (2015)

Site‐ and Enantioselective Iridium‐Catalyzed Desymmetric Mono‐Hydrogenation of 1,4‐Dienes
por: Wu, Haibo, et al.
Publicado: (2021)

Crystal structure of chlorido(piperidine-κN)(quinoline-2-carboxylato-κ(2) N,O)platinum(II)
por: Nguyen Thi Thanh, Chi, et al.
Publicado: (2014)

Chiral Pentacarboxycyclopentadiene-Based Brønsted Acid-Catalyzed Enantioselective Desymmetrization of Meso-Epoxides by 2-Mercaptobenzothiazoles
por: Yuan, Chao, et al.
Publicado: (2018)

Reducing Agent‐Mediated Nonenzymatic Conversion of 2‐Oxoglutarate to Succinate: Implications for Oxygenase Assays
por: Khan, Amjad, et al.
Publicado: (2020)

Direct alkylation of N,N-dialkyl benzamides with methyl sulfides under transition metal-free conditions
por: Bao, Can-Can, et al.
Publicado: (2021)

Enantioselective Synthesis of Chiral Cyclopent‐2‐enones by Nickel‐Catalyzed Desymmetrization of Malonate Esters
por: Karad, Somnath Narayan, et al.
Publicado: (2018)

A palladium catalyzed asymmetric desymmetrization approach to enantioenriched 1,3-disubstituted isoindolines
por: Dethe, Dattatraya H., et al.
Publicado: (2023)

Copper-Catalyzed N-Arylation of Amides Using (S)-N-Methylpyrrolidine-2-carboxylate as the Ligand
por: Wang, Chaoyu, et al.
Publicado: (2010)

Biochemical and structural investigations clarify the substrate selectivity of the 2-oxoglutarate oxygenase JMJD6
por: Islam, Md. Saiful, et al.
Publicado: (2019)

[Co(TPP)]‐Catalyzed Formation of Substituted Piperidines
por: Lankelma, Marianne, et al.
Publicado: (2019)

Desymmetrization of meso-Dibromocycloalkenes through Copper(I)-Catalyzed Asymmetric Allylic Substitution with Organolithium Reagents
por: Goh, Shermin S., et al.
Publicado: (2018)

Carboxylate Catalyzed Isomerization of β,γ‐Unsaturated N‐Acetylcysteamine Thioesters
por: Riuttamäki, Saara, et al.
Publicado: (2022)

N-Phenylpiperidine-1-carbothioamide
por: Li, Yu-Feng, et al.
Publicado: (2008)

Salt-stabilized alkylzinc pivalates: versatile reagents for cobalt-catalyzed selective 1,2-dialkylation
por: Lin, Jie, et al.
Publicado: (2023)

Human Oxygenase Variants Employing a Single Protein Fe(II) Ligand Are Catalytically Active
por: Brasnett, Amelia, et al.
Publicado: (2021)

Is JmjC Oxygenase Catalysis Limited to Demethylation?**
por: Hopkinson, Richard J, et al.
Publicado: (2013)

Asparagine and Aspartate Hydroxylation of the Cytoskeletal Ankyrin Family Is Catalyzed by Factor-inhibiting Hypoxia-inducible Factor
por: Yang, Ming, et al.
Publicado: (2011)

Chiral Brønsted Acid‐Catalyzed Asymmetric Synthesis of N‐Aryl‐cis‐aziridine Carboxylate Esters
por: Bew, Sean P., et al.
Publicado: (2017)

Cation–π Interactions Contribute to Substrate Recognition in γ‐Butyrobetaine Hydroxylase Catalysis
por: Kamps, Jos J. A. G., et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_8va0ll83lqu12g4pam62k04ggf