A Designed Conformational Shift To Control Protein Binding Specificity**

In a conformational selection scenario, manipulating the populations of binding-competent states should be expected to affect protein binding. We demonstrate how in silico designed point mutations within the core of ubiquitin, remote from the binding interface, change the binding specificity by shif...

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Detalles Bibliográficos
Autores principales: Michielssens, Servaas, Peters, Jan Henning, Ban, David, Pratihar, Supriya, Seeliger, Daniel, Sharma, Monika, Giller, Karin, Sabo, Thomas Michael, Becker, Stefan, Lee, Donghan, Griesinger, Christian, de Groot, Bert L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: WILEY-VCH Verlag 2014
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4497613/
https://www.ncbi.nlm.nih.gov/pubmed/25115701
http://dx.doi.org/10.1002/anie.201403102

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