Cargando…

Abnormal Accumulation of Collagen Type I Due to the Loss of Discoidin Domain Receptor 2 (Ddr2) Promotes Testicular Interstitial Dysfunction

BACKGROUND: Loss of functional allele for discoidin domain receptor 2 (Ddr2) results in impaired Leydig cell response to luteinizing hormone (LH), low testosterone production and arrested spermatogenesis in older male Ddr2(slie/slie) mice. However, the underlying mechanism responsible for this pheno...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhu, Chu-chao, Tang, Bin, Su, Jin, Zhao, Hu, Bu, Xin, Li, Zhen, Zhao, Jie, Gong, Wei-dong, Wu, Zhi-qun, Yao, Li-bo, Li, Wei, Zhang, Yuan-qiang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4497730/ https://www.ncbi.nlm.nih.gov/pubmed/26158267 http://dx.doi.org/10.1371/journal.pone.0131947

Ejemplares similares

Spatial localisation of Discoidin Domain Receptor 2 (DDR2) signalling is dependent on its collagen binding and kinase activity
por: Luczynski, Maciej T., et al.
Publicado: (2018)

Inhibitors of Discoidin Domain Receptor (DDR) Kinases for Cancer and Inflammation
por: Denny, William A., et al.
Publicado: (2021)

Discoidin Domain Receptors, DDR1b and DDR2, Promote Tumour Growth within Collagen but DDR1b Suppresses Experimental Lung Metastasis in HT1080 Xenografts
por: Wasinski, Benjamin, et al.
Publicado: (2020)

ADAM10 controls collagen signaling and cell migration on collagen by shedding the ectodomain of discoidin domain receptor 1 (DDR1)
por: Shitomi, Yasuyuki, et al.
Publicado: (2015)

Collagen binding specificity of the discoidin domain receptors: Binding sites on collagens II and III and molecular determinants for collagen IV recognition by DDR1
por: Xu, Huifang, et al.
Publicado: (2011)

TWIST1 induces expression of Discoidin Domain Receptor2 (DDR2) to Promote Ovarian Cancer Metastasis
por: Grither, Whitney R., et al.
Publicado: (2018)

Exploring the Cellular and Molecular Mechanism of Discoidin Domain Receptors (DDR1 and DDR2) in Bone Formation, Regeneration, and Its Associated Disease Conditions
por: Mariadoss, Arokia Vijaya Anand, et al.
Publicado: (2023)

Discoidin Domain Receptor-1 (DDR1) is Involved in Angiolymphatic Invasion in Oral Cancer
por: Chen, Yu-Lian, et al.
Publicado: (2020)

Periostin interaction with discoidin domain receptor-1 (DDR1) promotes cartilage degeneration
por: Han, Tianzhen, et al.
Publicado: (2020)

Targeting Discoidin Domain Receptors DDR1 and DDR2 overcomes matrix‐mediated tumor cell adaptation and tolerance to BRAF‐targeted therapy in melanoma
por: Berestjuk, Ilona, et al.
Publicado: (2021)

Expression and subcellular localization of Discoidin Domain Receptor 1 (DDR1) define prostate cancer aggressiveness
por: Bonfil, R. Daniel, et al.
Publicado: (2021)

The pronounced high expression of discoidin domain receptor 2 in human interstitial lung diseases
por: Bian, Huan, et al.
Publicado: (2018)

The tyrosine kinase inhibitor nilotinib targets the discoidin domain receptor DDR2 in calcific aortic valve stenosis
por: Carracedo, Miguel, et al.
Publicado: (2022)

Crystallographic Insight into Collagen Recognition by Discoidin Domain Receptor 2
por: Carafoli, Federico, et al.
Publicado: (2009)

Evaluation of discoidin domain receptor-2 (DDR2) expression level in normal, benign, and malignant human prostate tissues
por: Azemikhah, Mitra, et al.
Publicado: (2015)

Glycosylation at Asn(211) Regulates the Activation State of the Discoidin Domain Receptor 1 (DDR1)
por: Fu, Hsueh-Liang, et al.
Publicado: (2014)

Identification of novel driver mutations of the discoidin domain receptor 2 (DDR2) gene in squamous cell lung cancer of Chinese patients
por: Miao, Liyun, et al.
Publicado: (2014)

Deletion of discoidin domain receptor 2 attenuates renal interstitial fibrosis in a murine unilateral ureteral obstruction model
por: Li, Xi’an, et al.
Publicado: (2019)

Structure-Based Design of Tetrahydroisoquinoline-7-carboxamides as Selective Discoidin Domain Receptor 1 (DDR1) Inhibitors
por: Wang, Zhen, et al.
Publicado: (2016)

Control of craniofacial development by the collagen receptor, discoidin domain receptor 2
por: Mohamed, Fatma F, et al.
Publicado: (2023)

Collagen recognition and transmembrane signalling by discoidin domain receptors()
por: Carafoli, Federico, et al.
Publicado: (2013)

Expression and regulation of discoidin domain receptor 1 (DDR1) – a novel receptor for collagen – in normal human renal cells and patients with lupus nephritis
por: Boumpas, DT, et al.
Publicado: (2003)

Prevalence of Mutations in Discoidin Domain-Containing Receptor Tyrosine Kinase 2 (DDR2) in Squamous Cell Lung Cancers in Korean Patients
por: Lee, Mi-Sook, et al.
Publicado: (2017)

The C. elegans Discoidin Domain Receptor DDR-2 Modulates the Met-like RTK–JNK Signaling Pathway in Axon Regeneration
por: Hisamoto, Naoki, et al.
Publicado: (2016)

Silencing of Discoidin Domain Receptor-1 (DDR1) Concurrently Inhibits Multiple Steps of Metastasis Cascade in Gastric Cancer()
por: Yuge, Ryo, et al.
Publicado: (2018)

Identification of Receptor Tyrosine Kinase, Discoidin Domain Receptor 1 (DDR1), as a Potential Biomarker for Serous Ovarian Cancer
por: Quan, Jinhua, et al.
Publicado: (2011)

Corrigendum to “Spatial localisation of Discoidin Domain Receptor 2 (DDR2) signalling is dependent on its collagen binding and kinase activity” [Biochem. Biophys. Res. Commun. 501 (1) (18 June 2018) 124–130]
por: Luczynski, Maciej T., et al.
Publicado: (2018)

Discoidin Domain Receptor 1 (DDR1) tyrosine kinase is upregulated in PKD kidneys but does not play a role in the pathogenesis of polycystic kidney disease
por: Soomro, Irfana, et al.
Publicado: (2019)

Discoidin domain receptor 1 (DDR1) ablation promotes tissue fibrosis and hypoxia to induce aggressive basal-like breast cancers
por: Takai, Ken, et al.
Publicado: (2018)

Discoidin Domain Receptor Tyrosine Kinase 1 (DDR1): A Novel Predictor for Recurrence of Hepatocellular Carcinoma After Curative Resection
por: Xu, Meng, et al.
Publicado: (2021)

Recent Advances in the Role of Discoidin Domain Receptor Tyrosine Kinase 1 and Discoidin Domain Receptor Tyrosine Kinase 2 in Breast and Ovarian Cancer
por: Chen, Li, et al.
Publicado: (2021)

The collagen structure of C1q induces wound healing by engaging discoidin domain receptor 2
por: Hayuningtyas, Ria Aryani, et al.
Publicado: (2021)

Endothelial discoidin domain receptor 1 senses flow to modulate YAP activation
por: Liu, Jiayu, et al.
Publicado: (2023)

Inhibition of discoidin domain receptor (DDR)-1 with nilotinib alters CSF miRNAs and is associated with reduced inflammation and vascular fibrosis in Alzheimer’s disease
por: Stevenson, Max, et al.
Publicado: (2023)

Discoidin domain receptor 1a (DDR1a) confers 5-fluorouracil cytotoxicity in LoVo cell via PI3K/AKT/Bcl-2 pathway
por: Xiong, Bin, et al.
Publicado: (2022)

Recombinant Collagen Engineered to Bind to Discoidin Domain Receptor Functions as a Receptor Inhibitor
por: An, Bo, et al.
Publicado: (2016)

Type I collagen fibrils and discoidin domain receptor 1 set invadosomes straight
por: Moreau, Violaine, et al.
Publicado: (2015)

Targeting Discoidin Domain Receptor 1 (DDR1) Signaling and Its Crosstalk with β(1)-Integrin Emerges as a Key Factor for Breast Cancer Chemosensitization upon Collagen Type 1 Binding
por: Baltes, Fabian, et al.
Publicado: (2020)

Type I collagen aging impairs discoidin domain receptor 2-mediated tumor cell growth suppression
por: Saby, Charles, et al.
Publicado: (2016)

2-Amino-2,3-dihydro-1H-indene-5-carboxamide-Based Discoidin Domain Receptor 1 (DDR1) Inhibitors: Design, Synthesis, and in Vivo Antipancreatic Cancer Efficacy
por: Zhu, Dongsheng, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_akose1d3ncca2i1aq1opvefjh0