Prospective Cohort Study with Active Surveillance for Fever in Four Dengue Endemic Countries in Latin America

To prepare for a Phase III dengue vaccine efficacy trial, 20 investigational sites were selected for this observational study to identify dengue infections in a closed cohort (N = 3,000 children 9–16 years of age). Of 255 acute febrile episodes experienced by 235 children, 50 (21.3%) were considered...

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Detalles Bibliográficos
Autores principales: Dayan, Gustavo, Arredondo, Jose L., Carrasquilla, Gabriel, Deseda, Carmen C., Dietze, Reynaldo, Luz, Kleber, Costa, Maria Selma N., Cunha, Rivaldo V., Rey, Luis C., Morales, Javier, Reynales, Humberto, Miranda, Maria, Zambrano, Betzana, Rivas, Enrique, Garbes, Pedro, Noriega, Fernando
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society of Tropical Medicine and Hygiene 2015
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4497892/
https://www.ncbi.nlm.nih.gov/pubmed/26013373
http://dx.doi.org/10.4269/ajtmh.13-0663
Descripción
Sumario:To prepare for a Phase III dengue vaccine efficacy trial, 20 investigational sites were selected for this observational study to identify dengue infections in a closed cohort (N = 3,000 children 9–16 years of age). Of 255 acute febrile episodes experienced by 235 children, 50 (21.3%) were considered serologically probable dengue, and 18 (7.7%) were considered virologically confirmed (i.e., dengue NS1 antigen positive) dengue cases. Considering the disease-free and at-risk period from study start to onset of symptoms, the overall incidence density of acute febrile episodes was 17.7 per 100 person-years of follow-up, ranging from 15.3 in Colombia to 22.0 in Puerto Rico. This study showed that all sites were capable of capturing and following up acute febrile episodes within a specific timeframe among the established cohort and to detect dengue cases.

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