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Signaling through the Phosphatidylinositol 3-Kinase (PI3K)/Mammalian Target of Rapamycin (mTOR) Axis Is Responsible for Aerobic Glycolysis mediated by Glucose Transporter in Epidermal Growth Factor Receptor (EGFR)-mutated Lung Adenocarcinoma

Oncogenic epidermal growth factor receptor (EGFR) signaling plays an important role in regulating global metabolic pathways, including aerobic glycolysis, the pentose phosphate pathway (PPP), and pyrimidine biosynthesis. However, the molecular mechanism by which EGFR signaling regulates cancer cell...

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Detalles Bibliográficos
Autores principales:	Makinoshima, Hideki, Takita, Masahiro, Saruwatari, Koichi, Umemura, Shigeki, Obata, Yuuki, Ishii, Genichiro, Matsumoto, Shingo, Sugiyama, Eri, Ochiai, Atsushi, Abe, Ryo, Goto, Koichi, Esumi, Hiroyasu, Tsuchihara, Katsuya
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2015
Materias:	Metabolism
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4498084/ https://www.ncbi.nlm.nih.gov/pubmed/26023239 http://dx.doi.org/10.1074/jbc.M115.660498

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