Tetrahydroisoquinolines affect the whole-cell phenotype of Mycobacterium tuberculosis by inhibiting the ATP-dependent MurE ligase

OBJECTIVES: (S)-Leucoxine, isolated from the Colombian Lauraceae tree Rhodostemonodaphne crenaticupula Madriñan, was found to inhibit the growth of Mycobacterium tuberculosis H(37)Rv. A biomimetic approach for the chemical synthesis of a wide array of 1-substituted tetrahydroisoquinolines was undert...

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Detalles Bibliográficos
Autores principales: Guzman, Juan D., Pesnot, Thomas, Barrera, Diana A., Davies, Heledd M., McMahon, Eleanor, Evangelopoulos, Dimitrios, Mortazavi, Parisa N., Munshi, Tulika, Maitra, Arundhati, Lamming, Eleanor D., Angell, Richard, Gershater, Markus C., Redmond, Joanna M., Needham, Deborah, Ward, John M., Cuca, Luis E., Hailes, Helen C., Bhakta, Sanjib
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4498294/
https://www.ncbi.nlm.nih.gov/pubmed/25656411
http://dx.doi.org/10.1093/jac/dkv010

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