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Curcumin improves synaptic plasticity impairment induced by HIV-1gp120 V3 loop
Curcumin has been shown to significantly improve spatial memory impairment induced by HIV-1 gp120 V3 in rats, but the electrophysiological mechanism remains unknown. Using extracellular microelectrode recording techniques, this study confirmed that the gp120 V3 loop could suppress long-term potentia...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4498354/ https://www.ncbi.nlm.nih.gov/pubmed/26199609 http://dx.doi.org/10.4103/1673-5374.158358 |
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author | Shen, Ling-ling Jiang, Ming-liang Liu, Si-si Cai, Min-chun Hong, Zhong-qiu Lin, Li-qing Xing, Yan-yan Chen, Gui-lin Pan, Rui Yang, Li-juan Xu, Ying Dong, Jun |
author_facet | Shen, Ling-ling Jiang, Ming-liang Liu, Si-si Cai, Min-chun Hong, Zhong-qiu Lin, Li-qing Xing, Yan-yan Chen, Gui-lin Pan, Rui Yang, Li-juan Xu, Ying Dong, Jun |
author_sort | Shen, Ling-ling |
collection | PubMed |
description | Curcumin has been shown to significantly improve spatial memory impairment induced by HIV-1 gp120 V3 in rats, but the electrophysiological mechanism remains unknown. Using extracellular microelectrode recording techniques, this study confirmed that the gp120 V3 loop could suppress long-term potentiation in the rat hippocampal CA1 region and synaptic plasticity, and that curcumin could antagonize these inhibitory effects. Using a Fura-2/AM calcium ion probe, we found that curcumin resisted the effects of the gp120 V3 loop on hippocampal synaptosomes and decreased Ca(2+) concentration in synaptosomes. This effect of curcumin was identical to nimodipine, suggesting that curcumin improved the inhibitory effects of gp120 on synaptic plasticity, ameliorated damage caused to the central nervous system, and might be a potential neuroprotective drug. |
format | Online Article Text |
id | pubmed-4498354 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-44983542015-07-21 Curcumin improves synaptic plasticity impairment induced by HIV-1gp120 V3 loop Shen, Ling-ling Jiang, Ming-liang Liu, Si-si Cai, Min-chun Hong, Zhong-qiu Lin, Li-qing Xing, Yan-yan Chen, Gui-lin Pan, Rui Yang, Li-juan Xu, Ying Dong, Jun Neural Regen Res Research Article Curcumin has been shown to significantly improve spatial memory impairment induced by HIV-1 gp120 V3 in rats, but the electrophysiological mechanism remains unknown. Using extracellular microelectrode recording techniques, this study confirmed that the gp120 V3 loop could suppress long-term potentiation in the rat hippocampal CA1 region and synaptic plasticity, and that curcumin could antagonize these inhibitory effects. Using a Fura-2/AM calcium ion probe, we found that curcumin resisted the effects of the gp120 V3 loop on hippocampal synaptosomes and decreased Ca(2+) concentration in synaptosomes. This effect of curcumin was identical to nimodipine, suggesting that curcumin improved the inhibitory effects of gp120 on synaptic plasticity, ameliorated damage caused to the central nervous system, and might be a potential neuroprotective drug. Medknow Publications & Media Pvt Ltd 2015-06 /pmc/articles/PMC4498354/ /pubmed/26199609 http://dx.doi.org/10.4103/1673-5374.158358 Text en Copyright: © Neural Regeneration Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Shen, Ling-ling Jiang, Ming-liang Liu, Si-si Cai, Min-chun Hong, Zhong-qiu Lin, Li-qing Xing, Yan-yan Chen, Gui-lin Pan, Rui Yang, Li-juan Xu, Ying Dong, Jun Curcumin improves synaptic plasticity impairment induced by HIV-1gp120 V3 loop |
title | Curcumin improves synaptic plasticity impairment induced by HIV-1gp120 V3 loop |
title_full | Curcumin improves synaptic plasticity impairment induced by HIV-1gp120 V3 loop |
title_fullStr | Curcumin improves synaptic plasticity impairment induced by HIV-1gp120 V3 loop |
title_full_unstemmed | Curcumin improves synaptic plasticity impairment induced by HIV-1gp120 V3 loop |
title_short | Curcumin improves synaptic plasticity impairment induced by HIV-1gp120 V3 loop |
title_sort | curcumin improves synaptic plasticity impairment induced by hiv-1gp120 v3 loop |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4498354/ https://www.ncbi.nlm.nih.gov/pubmed/26199609 http://dx.doi.org/10.4103/1673-5374.158358 |
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