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Acrylamide neurotoxicity on the cerebrum of weaning rats

The mechanism underlying acrylamide-induced neurotoxicity remains controversial. Previous studies have focused on acrylamide-induced toxicity in adult rodents, but neurotoxicity in weaning rats has not been investigated. To explore the neurotoxic effect of acrylamide on the developing brain, weaning...

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Autores principales: Tian, Su-min, Ma, Yu-xin, Shi, Jing, Lou, Ting-ye, Liu, Shuai-shuai, Li, Guo-ying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4498356/
https://www.ncbi.nlm.nih.gov/pubmed/26199611
http://dx.doi.org/10.4103/1673-5374.158357
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author Tian, Su-min
Ma, Yu-xin
Shi, Jing
Lou, Ting-ye
Liu, Shuai-shuai
Li, Guo-ying
author_facet Tian, Su-min
Ma, Yu-xin
Shi, Jing
Lou, Ting-ye
Liu, Shuai-shuai
Li, Guo-ying
author_sort Tian, Su-min
collection PubMed
description The mechanism underlying acrylamide-induced neurotoxicity remains controversial. Previous studies have focused on acrylamide-induced toxicity in adult rodents, but neurotoxicity in weaning rats has not been investigated. To explore the neurotoxic effect of acrylamide on the developing brain, weaning rats were gavaged with 0, 5, 15, and 30 mg/kg acrylamide for 4 consecutive weeks. No obvious neurotoxicity was observed in weaning rats in the low-dose acrylamide group (5 mg/kg). However, rats from the moderate- and high-dose acrylamide groups (15 and 30 mg/kg) had an abnormal gait. Furthermore, biochemical tests in these rats demonstrated that glutamate concentration was significantly reduced, and γ-aminobutyric acid content was significantly increased and was dependent on acrylamide dose. Immunohistochemical staining showed that in the cerebral cortex, γ-aminobutyric acid, glutamic acid decarboxylase and glial fibrillary acidic protein expression increased remarkably in the moderate- and high-dose acrylamide groups. These results indicate that in weaning rats, acrylamide is positively associated with neurotoxicity in a dose-dependent manner, which may correlate with upregulation of γ-aminobutyric acid and subsequent neuronal degeneration after the initial acrylamide exposure.
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spelling pubmed-44983562015-07-21 Acrylamide neurotoxicity on the cerebrum of weaning rats Tian, Su-min Ma, Yu-xin Shi, Jing Lou, Ting-ye Liu, Shuai-shuai Li, Guo-ying Neural Regen Res Research Article The mechanism underlying acrylamide-induced neurotoxicity remains controversial. Previous studies have focused on acrylamide-induced toxicity in adult rodents, but neurotoxicity in weaning rats has not been investigated. To explore the neurotoxic effect of acrylamide on the developing brain, weaning rats were gavaged with 0, 5, 15, and 30 mg/kg acrylamide for 4 consecutive weeks. No obvious neurotoxicity was observed in weaning rats in the low-dose acrylamide group (5 mg/kg). However, rats from the moderate- and high-dose acrylamide groups (15 and 30 mg/kg) had an abnormal gait. Furthermore, biochemical tests in these rats demonstrated that glutamate concentration was significantly reduced, and γ-aminobutyric acid content was significantly increased and was dependent on acrylamide dose. Immunohistochemical staining showed that in the cerebral cortex, γ-aminobutyric acid, glutamic acid decarboxylase and glial fibrillary acidic protein expression increased remarkably in the moderate- and high-dose acrylamide groups. These results indicate that in weaning rats, acrylamide is positively associated with neurotoxicity in a dose-dependent manner, which may correlate with upregulation of γ-aminobutyric acid and subsequent neuronal degeneration after the initial acrylamide exposure. Medknow Publications & Media Pvt Ltd 2015-06 /pmc/articles/PMC4498356/ /pubmed/26199611 http://dx.doi.org/10.4103/1673-5374.158357 Text en Copyright: © Neural Regeneration Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Tian, Su-min
Ma, Yu-xin
Shi, Jing
Lou, Ting-ye
Liu, Shuai-shuai
Li, Guo-ying
Acrylamide neurotoxicity on the cerebrum of weaning rats
title Acrylamide neurotoxicity on the cerebrum of weaning rats
title_full Acrylamide neurotoxicity on the cerebrum of weaning rats
title_fullStr Acrylamide neurotoxicity on the cerebrum of weaning rats
title_full_unstemmed Acrylamide neurotoxicity on the cerebrum of weaning rats
title_short Acrylamide neurotoxicity on the cerebrum of weaning rats
title_sort acrylamide neurotoxicity on the cerebrum of weaning rats
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4498356/
https://www.ncbi.nlm.nih.gov/pubmed/26199611
http://dx.doi.org/10.4103/1673-5374.158357
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