Manganese-Enhanced MRI: Biological Applications in Neuroscience

Magnetic resonance imaging (MRI) is an excellent non-invasive tool to investigate biological systems. The administration of the paramagnetic divalent ion manganese (Mn(2+)) enhances MRI contrast in vivo. Due to similarities between Mn(2+) and calcium (Ca(2+)), the premise of manganese-enhanced MRI (...

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Autores principales: Malheiros, Jackeline Moraes, Paiva, Fernando Fernandes, Longo, Beatriz Monteiro, Hamani, Clement, Covolan, Luciene
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2015
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4498388/
https://www.ncbi.nlm.nih.gov/pubmed/26217304
http://dx.doi.org/10.3389/fneur.2015.00161
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author Malheiros, Jackeline Moraes
Paiva, Fernando Fernandes
Longo, Beatriz Monteiro
Hamani, Clement
Covolan, Luciene
author_facet Malheiros, Jackeline Moraes
Paiva, Fernando Fernandes
Longo, Beatriz Monteiro
Hamani, Clement
Covolan, Luciene
author_sort Malheiros, Jackeline Moraes
collection PubMed
description Magnetic resonance imaging (MRI) is an excellent non-invasive tool to investigate biological systems. The administration of the paramagnetic divalent ion manganese (Mn(2+)) enhances MRI contrast in vivo. Due to similarities between Mn(2+) and calcium (Ca(2+)), the premise of manganese-enhanced MRI (MEMRI) is that the former may enter neurons and other excitable cells through voltage-gated Ca(2+) channels. As such, MEMRI has been used to trace neuronal pathways, define morphological boundaries, and study connectivity in morphological and functional imaging studies. In this article, we provide a brief overview of MEMRI and discuss recently published data to illustrate the usefulness of this method, particularly in animal models.
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spelling pubmed-44983882015-07-27 Manganese-Enhanced MRI: Biological Applications in Neuroscience Malheiros, Jackeline Moraes Paiva, Fernando Fernandes Longo, Beatriz Monteiro Hamani, Clement Covolan, Luciene Front Neurol Neuroscience Magnetic resonance imaging (MRI) is an excellent non-invasive tool to investigate biological systems. The administration of the paramagnetic divalent ion manganese (Mn(2+)) enhances MRI contrast in vivo. Due to similarities between Mn(2+) and calcium (Ca(2+)), the premise of manganese-enhanced MRI (MEMRI) is that the former may enter neurons and other excitable cells through voltage-gated Ca(2+) channels. As such, MEMRI has been used to trace neuronal pathways, define morphological boundaries, and study connectivity in morphological and functional imaging studies. In this article, we provide a brief overview of MEMRI and discuss recently published data to illustrate the usefulness of this method, particularly in animal models. Frontiers Media S.A. 2015-07-10 /pmc/articles/PMC4498388/ /pubmed/26217304 http://dx.doi.org/10.3389/fneur.2015.00161 Text en Copyright © 2015 Malheiros, Paiva, Longo, Hamani and Covolan. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Malheiros, Jackeline Moraes
Paiva, Fernando Fernandes
Longo, Beatriz Monteiro
Hamani, Clement
Covolan, Luciene
Manganese-Enhanced MRI: Biological Applications in Neuroscience
title Manganese-Enhanced MRI: Biological Applications in Neuroscience
title_full Manganese-Enhanced MRI: Biological Applications in Neuroscience
title_fullStr Manganese-Enhanced MRI: Biological Applications in Neuroscience
title_full_unstemmed Manganese-Enhanced MRI: Biological Applications in Neuroscience
title_short Manganese-Enhanced MRI: Biological Applications in Neuroscience
title_sort manganese-enhanced mri: biological applications in neuroscience
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4498388/
https://www.ncbi.nlm.nih.gov/pubmed/26217304
http://dx.doi.org/10.3389/fneur.2015.00161
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AT longobeatrizmonteiro manganeseenhancedmribiologicalapplicationsinneuroscience
AT hamaniclement manganeseenhancedmribiologicalapplicationsinneuroscience
AT covolanluciene manganeseenhancedmribiologicalapplicationsinneuroscience

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