A Convenient Synthetic Protocol to 1,2-Bis(dialkylphosphino)ethanes

1,2-Bis(dialkylphosphino)ethanes are readily prepared from the parent phosphine oxides, via a novel sodium aluminium hydride/sodium hydride reduction protocol of intermediate chlorophosphonium chlorides. This approach is amenable to multi-gram syntheses, utilises readily available and inexpensive re...

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Autores principales: Doyle, Laurence R, Heath, Alex, Low, Choon Heng, Ashley, Andrew E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: WILEY-VCH Verlag 2014
Materias:
Updates
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4498470/
https://www.ncbi.nlm.nih.gov/pubmed/26190960
http://dx.doi.org/10.1002/adsc.201300787
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author Doyle, Laurence R
Heath, Alex
Low, Choon Heng
Ashley, Andrew E
author_facet Doyle, Laurence R
Heath, Alex
Low, Choon Heng
Ashley, Andrew E
author_sort Doyle, Laurence R
collection PubMed
description 1,2-Bis(dialkylphosphino)ethanes are readily prepared from the parent phosphine oxides, via a novel sodium aluminium hydride/sodium hydride reduction protocol of intermediate chlorophosphonium chlorides. This approach is amenable to multi-gram syntheses, utilises readily available and inexpensive reagents, and benefits from a facile non-aqueous work-up in the final reductive step.
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spelling pubmed-44984702015-07-15 A Convenient Synthetic Protocol to 1,2-Bis(dialkylphosphino)ethanes Doyle, Laurence R Heath, Alex Low, Choon Heng Ashley, Andrew E Adv Synth Catal Updates 1,2-Bis(dialkylphosphino)ethanes are readily prepared from the parent phosphine oxides, via a novel sodium aluminium hydride/sodium hydride reduction protocol of intermediate chlorophosphonium chlorides. This approach is amenable to multi-gram syntheses, utilises readily available and inexpensive reagents, and benefits from a facile non-aqueous work-up in the final reductive step. WILEY-VCH Verlag 2014-02-10 2014-02-02 /pmc/articles/PMC4498470/ /pubmed/26190960 http://dx.doi.org/10.1002/adsc.201300787 Text en © 2014 The authors. Published by Wiley-VCH Verlag GmbH &Co. KGaA. This is an open access article under the terms of the Creative Commons Attribution Non-Commercial NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. https://creativecommons.org/licenses/by-nc-nd/4.0/ © 2014 The authors. Published by Wiley-VCH Verlag GmbH &Co. KGaA. This is an open access article under the terms of the Creative Commons Attribution Non-Commercial NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Updates
Doyle, Laurence R
Heath, Alex
Low, Choon Heng
Ashley, Andrew E
A Convenient Synthetic Protocol to 1,2-Bis(dialkylphosphino)ethanes
title A Convenient Synthetic Protocol to 1,2-Bis(dialkylphosphino)ethanes
title_full A Convenient Synthetic Protocol to 1,2-Bis(dialkylphosphino)ethanes
title_fullStr A Convenient Synthetic Protocol to 1,2-Bis(dialkylphosphino)ethanes
title_full_unstemmed A Convenient Synthetic Protocol to 1,2-Bis(dialkylphosphino)ethanes
title_short A Convenient Synthetic Protocol to 1,2-Bis(dialkylphosphino)ethanes
title_sort convenient synthetic protocol to 1,2-bis(dialkylphosphino)ethanes
topic Updates
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4498470/
https://www.ncbi.nlm.nih.gov/pubmed/26190960
http://dx.doi.org/10.1002/adsc.201300787
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