Mobile element insertions are frequent in oesophageal adenocarcinomas and can mislead paired-end sequencing analysis

BACKGROUND: Mobile elements are active in the human genome, both in the germline and cancers, where they can mutate driver genes. RESULTS: While analysing whole genome paired-end sequencing of oesophageal adenocarcinomas to find genomic rearrangements, we identified three ways in which new mobile el...

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Detalles Bibliográficos
Autores principales: Paterson, Anna L., Weaver, Jamie M.J., Eldridge, Matthew D., Tavaré, Simon, Fitzgerald, Rebecca C., Edwards, Paul A.W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4498532/
https://www.ncbi.nlm.nih.gov/pubmed/26159513
http://dx.doi.org/10.1186/s12864-015-1685-z

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