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Infiltrative Cardiomyopathies
Infiltrative cardiomyopathies can result from a wide spectrum of both inherited and acquired conditions with varying systemic manifestations. They portend an adverse prognosis, with only a few exceptions (ie, glycogen storage disease), where early diagnosis can result in potentially curative treatme...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Libertas Academica
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4498662/ https://www.ncbi.nlm.nih.gov/pubmed/26244036 http://dx.doi.org/10.4137/CMC.S19706 |
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author | Bejar, David Colombo, Paolo C Latif, Farhana Yuzefpolskaya, Melana |
author_facet | Bejar, David Colombo, Paolo C Latif, Farhana Yuzefpolskaya, Melana |
author_sort | Bejar, David |
collection | PubMed |
description | Infiltrative cardiomyopathies can result from a wide spectrum of both inherited and acquired conditions with varying systemic manifestations. They portend an adverse prognosis, with only a few exceptions (ie, glycogen storage disease), where early diagnosis can result in potentially curative treatment. The extent of cardiac abnormalities varies based on the degree of infiltration and results in increased ventricular wall thickness, chamber dilatation, and disruption of the conduction system. These changes often lead to the development of heart failure, atrioventricular (AV) block, and ventricular arrhythmia. Because these diseases are relatively rare, a high degree of clinical suspicion is important for diagnosis. Electrocardiography and echocardiography are helpful, but advanced techniques including cardiac magnetic resonance (CMR) and nuclear imaging are increasingly preferred. Treatment is dependent on the etiology and extent of the disease and involves medications, device therapy, and, in some cases, organ transplantation. Cardiac amyloid is the archetype of the infiltrative cardiomyopathies and is discussed in great detail in this review. |
format | Online Article Text |
id | pubmed-4498662 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Libertas Academica |
record_format | MEDLINE/PubMed |
spelling | pubmed-44986622015-08-04 Infiltrative Cardiomyopathies Bejar, David Colombo, Paolo C Latif, Farhana Yuzefpolskaya, Melana Clin Med Insights Cardiol Review Infiltrative cardiomyopathies can result from a wide spectrum of both inherited and acquired conditions with varying systemic manifestations. They portend an adverse prognosis, with only a few exceptions (ie, glycogen storage disease), where early diagnosis can result in potentially curative treatment. The extent of cardiac abnormalities varies based on the degree of infiltration and results in increased ventricular wall thickness, chamber dilatation, and disruption of the conduction system. These changes often lead to the development of heart failure, atrioventricular (AV) block, and ventricular arrhythmia. Because these diseases are relatively rare, a high degree of clinical suspicion is important for diagnosis. Electrocardiography and echocardiography are helpful, but advanced techniques including cardiac magnetic resonance (CMR) and nuclear imaging are increasingly preferred. Treatment is dependent on the etiology and extent of the disease and involves medications, device therapy, and, in some cases, organ transplantation. Cardiac amyloid is the archetype of the infiltrative cardiomyopathies and is discussed in great detail in this review. Libertas Academica 2015-07-08 /pmc/articles/PMC4498662/ /pubmed/26244036 http://dx.doi.org/10.4137/CMC.S19706 Text en © 2015 the author(s), publisher and licensee Libertas Academica Ltd. This is an open access article published under the Creative Commons CC-BY-NC 3.0 License. |
spellingShingle | Review Bejar, David Colombo, Paolo C Latif, Farhana Yuzefpolskaya, Melana Infiltrative Cardiomyopathies |
title | Infiltrative Cardiomyopathies |
title_full | Infiltrative Cardiomyopathies |
title_fullStr | Infiltrative Cardiomyopathies |
title_full_unstemmed | Infiltrative Cardiomyopathies |
title_short | Infiltrative Cardiomyopathies |
title_sort | infiltrative cardiomyopathies |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4498662/ https://www.ncbi.nlm.nih.gov/pubmed/26244036 http://dx.doi.org/10.4137/CMC.S19706 |
work_keys_str_mv | AT bejardavid infiltrativecardiomyopathies AT colombopaoloc infiltrativecardiomyopathies AT latiffarhana infiltrativecardiomyopathies AT yuzefpolskayamelana infiltrativecardiomyopathies |