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Gefitinib upregulates death receptor 5 expression to mediate rmhTRAIL-induced apoptosis in Gefitinib-sensitive NSCLC cell line

BACKGROUND: Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) triggers apoptosis in tumor cells, but when used alone, it is not effective in the treatment of TRAIL-resistant tumors. Some studies have shown that gefitinib interacts with recombinant mutant human TRAIL (rmhTRAIL) to induc...

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Detalles Bibliográficos
Autores principales:	Yan, Dong, Ge, Yang, Deng, Haiteng, Chen, Wenming, An, Guangyu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove Medical Press 2015
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4498723/ https://www.ncbi.nlm.nih.gov/pubmed/26170696 http://dx.doi.org/10.2147/OTT.S73731

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