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Variability of Gross Tumor Volume in Nasopharyngeal Carcinoma Using (11)C-Choline and (18)F-FDG PET/CT
This study was conducted to evaluate the variability of gross tumor volume (GTV) using (11)C-Choline and (18)F-FDG PET/CT images for nasopharyngeal carcinomas boundary definition. Assessment consisted of inter-observer and inter-modality variation analysis. Four radiation oncologists were invited to...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4498791/ https://www.ncbi.nlm.nih.gov/pubmed/26161910 http://dx.doi.org/10.1371/journal.pone.0131801 |
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author | Jiang, Jun Wu, Hubing Huang, Meiyan Wu, Yao Wang, Quanshi Zhao, Jianqi Yang, Wei Chen, Wufan Feng, Qianjin |
author_facet | Jiang, Jun Wu, Hubing Huang, Meiyan Wu, Yao Wang, Quanshi Zhao, Jianqi Yang, Wei Chen, Wufan Feng, Qianjin |
author_sort | Jiang, Jun |
collection | PubMed |
description | This study was conducted to evaluate the variability of gross tumor volume (GTV) using (11)C-Choline and (18)F-FDG PET/CT images for nasopharyngeal carcinomas boundary definition. Assessment consisted of inter-observer and inter-modality variation analysis. Four radiation oncologists were invited to manually contour GTV by using PET/CT fusion obtained from a cohort of 12 patients with nasopharyngeal carcinoma (NPC) and who underwent both (11)C-Choline and (18)F-FDG scans. Student’s paired-sample t-test was performed for analyzing inter-observer and inter-modality variability. Semi-automatic segmentation methods, including thresholding and region growing, were also validated against the manual contouring of the two types of PET images. We observed no significant variation in the results obtained by different oncologists in terms of the same type of PET/CT volumes. Choline fusion volumes were significantly larger than the FDG volumes (p < 0.0001, mean ± SD = 18.21 ± 8.19). While significantly consistent results were obtained between the oncologists and the standard references in Choline volumes compared with those in FDG volumes (p = 0.0025). Simple semi-automatic delineation methods indicated that (11)C-Choline PET images could provide better results than FDG volumes (p = 0.076, CI = [–0.29, 0.025]). (11)C-Choline PET/CT may be more advantageous in GTV delineation for the radiotherapy of NPC than (18)F-FDG. Phantom simulations and clinical trials should be conducted to prove the possible improvement of the treatment outcome. |
format | Online Article Text |
id | pubmed-4498791 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-44987912015-07-17 Variability of Gross Tumor Volume in Nasopharyngeal Carcinoma Using (11)C-Choline and (18)F-FDG PET/CT Jiang, Jun Wu, Hubing Huang, Meiyan Wu, Yao Wang, Quanshi Zhao, Jianqi Yang, Wei Chen, Wufan Feng, Qianjin PLoS One Research Article This study was conducted to evaluate the variability of gross tumor volume (GTV) using (11)C-Choline and (18)F-FDG PET/CT images for nasopharyngeal carcinomas boundary definition. Assessment consisted of inter-observer and inter-modality variation analysis. Four radiation oncologists were invited to manually contour GTV by using PET/CT fusion obtained from a cohort of 12 patients with nasopharyngeal carcinoma (NPC) and who underwent both (11)C-Choline and (18)F-FDG scans. Student’s paired-sample t-test was performed for analyzing inter-observer and inter-modality variability. Semi-automatic segmentation methods, including thresholding and region growing, were also validated against the manual contouring of the two types of PET images. We observed no significant variation in the results obtained by different oncologists in terms of the same type of PET/CT volumes. Choline fusion volumes were significantly larger than the FDG volumes (p < 0.0001, mean ± SD = 18.21 ± 8.19). While significantly consistent results were obtained between the oncologists and the standard references in Choline volumes compared with those in FDG volumes (p = 0.0025). Simple semi-automatic delineation methods indicated that (11)C-Choline PET images could provide better results than FDG volumes (p = 0.076, CI = [–0.29, 0.025]). (11)C-Choline PET/CT may be more advantageous in GTV delineation for the radiotherapy of NPC than (18)F-FDG. Phantom simulations and clinical trials should be conducted to prove the possible improvement of the treatment outcome. Public Library of Science 2015-07-10 /pmc/articles/PMC4498791/ /pubmed/26161910 http://dx.doi.org/10.1371/journal.pone.0131801 Text en © 2015 Jiang et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Jiang, Jun Wu, Hubing Huang, Meiyan Wu, Yao Wang, Quanshi Zhao, Jianqi Yang, Wei Chen, Wufan Feng, Qianjin Variability of Gross Tumor Volume in Nasopharyngeal Carcinoma Using (11)C-Choline and (18)F-FDG PET/CT |
title | Variability of Gross Tumor Volume in Nasopharyngeal Carcinoma Using (11)C-Choline and (18)F-FDG PET/CT |
title_full | Variability of Gross Tumor Volume in Nasopharyngeal Carcinoma Using (11)C-Choline and (18)F-FDG PET/CT |
title_fullStr | Variability of Gross Tumor Volume in Nasopharyngeal Carcinoma Using (11)C-Choline and (18)F-FDG PET/CT |
title_full_unstemmed | Variability of Gross Tumor Volume in Nasopharyngeal Carcinoma Using (11)C-Choline and (18)F-FDG PET/CT |
title_short | Variability of Gross Tumor Volume in Nasopharyngeal Carcinoma Using (11)C-Choline and (18)F-FDG PET/CT |
title_sort | variability of gross tumor volume in nasopharyngeal carcinoma using (11)c-choline and (18)f-fdg pet/ct |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4498791/ https://www.ncbi.nlm.nih.gov/pubmed/26161910 http://dx.doi.org/10.1371/journal.pone.0131801 |
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