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Variability of Gross Tumor Volume in Nasopharyngeal Carcinoma Using (11)C-Choline and (18)F-FDG PET/CT

This study was conducted to evaluate the variability of gross tumor volume (GTV) using (11)C-Choline and (18)F-FDG PET/CT images for nasopharyngeal carcinomas boundary definition. Assessment consisted of inter-observer and inter-modality variation analysis. Four radiation oncologists were invited to...

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Autores principales: Jiang, Jun, Wu, Hubing, Huang, Meiyan, Wu, Yao, Wang, Quanshi, Zhao, Jianqi, Yang, Wei, Chen, Wufan, Feng, Qianjin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4498791/
https://www.ncbi.nlm.nih.gov/pubmed/26161910
http://dx.doi.org/10.1371/journal.pone.0131801
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author Jiang, Jun
Wu, Hubing
Huang, Meiyan
Wu, Yao
Wang, Quanshi
Zhao, Jianqi
Yang, Wei
Chen, Wufan
Feng, Qianjin
author_facet Jiang, Jun
Wu, Hubing
Huang, Meiyan
Wu, Yao
Wang, Quanshi
Zhao, Jianqi
Yang, Wei
Chen, Wufan
Feng, Qianjin
author_sort Jiang, Jun
collection PubMed
description This study was conducted to evaluate the variability of gross tumor volume (GTV) using (11)C-Choline and (18)F-FDG PET/CT images for nasopharyngeal carcinomas boundary definition. Assessment consisted of inter-observer and inter-modality variation analysis. Four radiation oncologists were invited to manually contour GTV by using PET/CT fusion obtained from a cohort of 12 patients with nasopharyngeal carcinoma (NPC) and who underwent both (11)C-Choline and (18)F-FDG scans. Student’s paired-sample t-test was performed for analyzing inter-observer and inter-modality variability. Semi-automatic segmentation methods, including thresholding and region growing, were also validated against the manual contouring of the two types of PET images. We observed no significant variation in the results obtained by different oncologists in terms of the same type of PET/CT volumes. Choline fusion volumes were significantly larger than the FDG volumes (p < 0.0001, mean ± SD = 18.21 ± 8.19). While significantly consistent results were obtained between the oncologists and the standard references in Choline volumes compared with those in FDG volumes (p = 0.0025). Simple semi-automatic delineation methods indicated that (11)C-Choline PET images could provide better results than FDG volumes (p = 0.076, CI = [–0.29, 0.025]). (11)C-Choline PET/CT may be more advantageous in GTV delineation for the radiotherapy of NPC than (18)F-FDG. Phantom simulations and clinical trials should be conducted to prove the possible improvement of the treatment outcome.
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spelling pubmed-44987912015-07-17 Variability of Gross Tumor Volume in Nasopharyngeal Carcinoma Using (11)C-Choline and (18)F-FDG PET/CT Jiang, Jun Wu, Hubing Huang, Meiyan Wu, Yao Wang, Quanshi Zhao, Jianqi Yang, Wei Chen, Wufan Feng, Qianjin PLoS One Research Article This study was conducted to evaluate the variability of gross tumor volume (GTV) using (11)C-Choline and (18)F-FDG PET/CT images for nasopharyngeal carcinomas boundary definition. Assessment consisted of inter-observer and inter-modality variation analysis. Four radiation oncologists were invited to manually contour GTV by using PET/CT fusion obtained from a cohort of 12 patients with nasopharyngeal carcinoma (NPC) and who underwent both (11)C-Choline and (18)F-FDG scans. Student’s paired-sample t-test was performed for analyzing inter-observer and inter-modality variability. Semi-automatic segmentation methods, including thresholding and region growing, were also validated against the manual contouring of the two types of PET images. We observed no significant variation in the results obtained by different oncologists in terms of the same type of PET/CT volumes. Choline fusion volumes were significantly larger than the FDG volumes (p < 0.0001, mean ± SD = 18.21 ± 8.19). While significantly consistent results were obtained between the oncologists and the standard references in Choline volumes compared with those in FDG volumes (p = 0.0025). Simple semi-automatic delineation methods indicated that (11)C-Choline PET images could provide better results than FDG volumes (p = 0.076, CI = [–0.29, 0.025]). (11)C-Choline PET/CT may be more advantageous in GTV delineation for the radiotherapy of NPC than (18)F-FDG. Phantom simulations and clinical trials should be conducted to prove the possible improvement of the treatment outcome. Public Library of Science 2015-07-10 /pmc/articles/PMC4498791/ /pubmed/26161910 http://dx.doi.org/10.1371/journal.pone.0131801 Text en © 2015 Jiang et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Jiang, Jun
Wu, Hubing
Huang, Meiyan
Wu, Yao
Wang, Quanshi
Zhao, Jianqi
Yang, Wei
Chen, Wufan
Feng, Qianjin
Variability of Gross Tumor Volume in Nasopharyngeal Carcinoma Using (11)C-Choline and (18)F-FDG PET/CT
title Variability of Gross Tumor Volume in Nasopharyngeal Carcinoma Using (11)C-Choline and (18)F-FDG PET/CT
title_full Variability of Gross Tumor Volume in Nasopharyngeal Carcinoma Using (11)C-Choline and (18)F-FDG PET/CT
title_fullStr Variability of Gross Tumor Volume in Nasopharyngeal Carcinoma Using (11)C-Choline and (18)F-FDG PET/CT
title_full_unstemmed Variability of Gross Tumor Volume in Nasopharyngeal Carcinoma Using (11)C-Choline and (18)F-FDG PET/CT
title_short Variability of Gross Tumor Volume in Nasopharyngeal Carcinoma Using (11)C-Choline and (18)F-FDG PET/CT
title_sort variability of gross tumor volume in nasopharyngeal carcinoma using (11)c-choline and (18)f-fdg pet/ct
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4498791/
https://www.ncbi.nlm.nih.gov/pubmed/26161910
http://dx.doi.org/10.1371/journal.pone.0131801
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