MLL-ELL fusion gene in an acute myelomonocytic leukemia patient transformed from acute promyelocytic leukemia

We report an extremely rare case of acute myelomonocytic leukemia (M4) with an MLL-ELL fusion gene lacking the PML-RARα rearrangement that transformed from hypergranular acute promyelocytic leukemia (APL) without showing any karyotypic evolution. The treatment was effective with chemotherapy for M4...

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Detalles Bibliográficos
Autores principales: Hu, Wang Qiang, Wang, Xiao Xia, Yang, Rong Rong, Yu, Kang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Ltd 2015
Materias:
Case Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4498851/
https://www.ncbi.nlm.nih.gov/pubmed/26185637
http://dx.doi.org/10.1002/ccr3.245
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author Hu, Wang Qiang
Wang, Xiao Xia
Yang, Rong Rong
Yu, Kang
author_facet Hu, Wang Qiang
Wang, Xiao Xia
Yang, Rong Rong
Yu, Kang
author_sort Hu, Wang Qiang
collection PubMed
description We report an extremely rare case of acute myelomonocytic leukemia (M4) with an MLL-ELL fusion gene lacking the PML-RARα rearrangement that transformed from hypergranular acute promyelocytic leukemia (APL) without showing any karyotypic evolution. The treatment was effective with chemotherapy for M4 and idarubicin plus a cytarabine-based chemotherapy protocol without ATRA.
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spelling pubmed-44988512015-07-16 MLL-ELL fusion gene in an acute myelomonocytic leukemia patient transformed from acute promyelocytic leukemia Hu, Wang Qiang Wang, Xiao Xia Yang, Rong Rong Yu, Kang Clin Case Rep Case Reports We report an extremely rare case of acute myelomonocytic leukemia (M4) with an MLL-ELL fusion gene lacking the PML-RARα rearrangement that transformed from hypergranular acute promyelocytic leukemia (APL) without showing any karyotypic evolution. The treatment was effective with chemotherapy for M4 and idarubicin plus a cytarabine-based chemotherapy protocol without ATRA. John Wiley & Sons, Ltd 2015-06 2015-04-09 /pmc/articles/PMC4498851/ /pubmed/26185637 http://dx.doi.org/10.1002/ccr3.245 Text en © 2015 The Authors. Clinical Case Reports published by John Wiley & Sons Ltd. http://creativecommons.org/licenses/by-nc/4.0/ This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Case Reports
Hu, Wang Qiang
Wang, Xiao Xia
Yang, Rong Rong
Yu, Kang
MLL-ELL fusion gene in an acute myelomonocytic leukemia patient transformed from acute promyelocytic leukemia
title MLL-ELL fusion gene in an acute myelomonocytic leukemia patient transformed from acute promyelocytic leukemia
title_full MLL-ELL fusion gene in an acute myelomonocytic leukemia patient transformed from acute promyelocytic leukemia
title_fullStr MLL-ELL fusion gene in an acute myelomonocytic leukemia patient transformed from acute promyelocytic leukemia
title_full_unstemmed MLL-ELL fusion gene in an acute myelomonocytic leukemia patient transformed from acute promyelocytic leukemia
title_short MLL-ELL fusion gene in an acute myelomonocytic leukemia patient transformed from acute promyelocytic leukemia
title_sort mll-ell fusion gene in an acute myelomonocytic leukemia patient transformed from acute promyelocytic leukemia
topic Case Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4498851/
https://www.ncbi.nlm.nih.gov/pubmed/26185637
http://dx.doi.org/10.1002/ccr3.245
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AT yangrongrong mllellfusiongeneinanacutemyelomonocyticleukemiapatienttransformedfromacutepromyelocyticleukemia
AT yukang mllellfusiongeneinanacutemyelomonocyticleukemiapatienttransformedfromacutepromyelocyticleukemia

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