Identification of ribonucleotide reductase mutation causing temperature-sensitivity of herpes simplex virus isolates from whitlow by deep sequencing

Herpes simplex virus 2 caused a genital ulcer, and a secondary herpetic whitlow appeared during acyclovir therapy. The secondary and recurrent whitlow isolates were acyclovir-resistant and temperature-sensitive in contrast to a genital isolate. We identified the ribonucleotide reductase mutation res...

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Detalles Bibliográficos
Autores principales: Daikoku, Tohru, Oyama, Yukari, Yajima, Misako, Sekizuka, Tsuyoshi, Kuroda, Makoto, Shimada, Yuka, Takehara, Kazuhiko, Miwa, Naoko, Okuda, Tomoko, Sata, Tetsutaro, Shiraki, Kimiyasu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Ltd 2015
Materias:
Case Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4498863/
https://www.ncbi.nlm.nih.gov/pubmed/26185649
http://dx.doi.org/10.1002/ccr3.270
Descripción
Sumario:Herpes simplex virus 2 caused a genital ulcer, and a secondary herpetic whitlow appeared during acyclovir therapy. The secondary and recurrent whitlow isolates were acyclovir-resistant and temperature-sensitive in contrast to a genital isolate. We identified the ribonucleotide reductase mutation responsible for temperature-sensitivity by deep-sequencing analysis.

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