Identification of ribonucleotide reductase mutation causing temperature-sensitivity of herpes simplex virus isolates from whitlow by deep sequencing

Herpes simplex virus 2 caused a genital ulcer, and a secondary herpetic whitlow appeared during acyclovir therapy. The secondary and recurrent whitlow isolates were acyclovir-resistant and temperature-sensitive in contrast to a genital isolate. We identified the ribonucleotide reductase mutation res...

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Autores principales: Daikoku, Tohru, Oyama, Yukari, Yajima, Misako, Sekizuka, Tsuyoshi, Kuroda, Makoto, Shimada, Yuka, Takehara, Kazuhiko, Miwa, Naoko, Okuda, Tomoko, Sata, Tetsutaro, Shiraki, Kimiyasu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Ltd 2015
Materias:
Case Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4498863/
https://www.ncbi.nlm.nih.gov/pubmed/26185649
http://dx.doi.org/10.1002/ccr3.270
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author Daikoku, Tohru
Oyama, Yukari
Yajima, Misako
Sekizuka, Tsuyoshi
Kuroda, Makoto
Shimada, Yuka
Takehara, Kazuhiko
Miwa, Naoko
Okuda, Tomoko
Sata, Tetsutaro
Shiraki, Kimiyasu
author_facet Daikoku, Tohru
Oyama, Yukari
Yajima, Misako
Sekizuka, Tsuyoshi
Kuroda, Makoto
Shimada, Yuka
Takehara, Kazuhiko
Miwa, Naoko
Okuda, Tomoko
Sata, Tetsutaro
Shiraki, Kimiyasu
author_sort Daikoku, Tohru
collection PubMed
description Herpes simplex virus 2 caused a genital ulcer, and a secondary herpetic whitlow appeared during acyclovir therapy. The secondary and recurrent whitlow isolates were acyclovir-resistant and temperature-sensitive in contrast to a genital isolate. We identified the ribonucleotide reductase mutation responsible for temperature-sensitivity by deep-sequencing analysis.
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spelling pubmed-44988632015-07-16 Identification of ribonucleotide reductase mutation causing temperature-sensitivity of herpes simplex virus isolates from whitlow by deep sequencing Daikoku, Tohru Oyama, Yukari Yajima, Misako Sekizuka, Tsuyoshi Kuroda, Makoto Shimada, Yuka Takehara, Kazuhiko Miwa, Naoko Okuda, Tomoko Sata, Tetsutaro Shiraki, Kimiyasu Clin Case Rep Case Reports Herpes simplex virus 2 caused a genital ulcer, and a secondary herpetic whitlow appeared during acyclovir therapy. The secondary and recurrent whitlow isolates were acyclovir-resistant and temperature-sensitive in contrast to a genital isolate. We identified the ribonucleotide reductase mutation responsible for temperature-sensitivity by deep-sequencing analysis. John Wiley & Sons, Ltd 2015-06 2015-04-22 /pmc/articles/PMC4498863/ /pubmed/26185649 http://dx.doi.org/10.1002/ccr3.270 Text en © 2015 The Authors. Clinical Case Reports published by John Wiley & Sons Ltd. http://creativecommons.org/licenses/by-nc/4.0/ This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Case Reports
Daikoku, Tohru
Oyama, Yukari
Yajima, Misako
Sekizuka, Tsuyoshi
Kuroda, Makoto
Shimada, Yuka
Takehara, Kazuhiko
Miwa, Naoko
Okuda, Tomoko
Sata, Tetsutaro
Shiraki, Kimiyasu
Identification of ribonucleotide reductase mutation causing temperature-sensitivity of herpes simplex virus isolates from whitlow by deep sequencing
title Identification of ribonucleotide reductase mutation causing temperature-sensitivity of herpes simplex virus isolates from whitlow by deep sequencing
title_full Identification of ribonucleotide reductase mutation causing temperature-sensitivity of herpes simplex virus isolates from whitlow by deep sequencing
title_fullStr Identification of ribonucleotide reductase mutation causing temperature-sensitivity of herpes simplex virus isolates from whitlow by deep sequencing
title_full_unstemmed Identification of ribonucleotide reductase mutation causing temperature-sensitivity of herpes simplex virus isolates from whitlow by deep sequencing
title_short Identification of ribonucleotide reductase mutation causing temperature-sensitivity of herpes simplex virus isolates from whitlow by deep sequencing
title_sort identification of ribonucleotide reductase mutation causing temperature-sensitivity of herpes simplex virus isolates from whitlow by deep sequencing
topic Case Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4498863/
https://www.ncbi.nlm.nih.gov/pubmed/26185649
http://dx.doi.org/10.1002/ccr3.270
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