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Cell-free fetal DNA in the maternal circulation originates from the cytotrophoblast: proof from an unique case
Noninvasive prenatal testing (NIPT) and direct karyotyping of cytotrophoblast were normal for a male fetus, but cultured chorionic villus mesenchymal cells and umbilical cord fibroblasts showed nonmosaic trisomy 18. This observation provides direct evidence for the cytotrophoblastic origin of cell-f...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley & Sons, Ltd
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4498868/ https://www.ncbi.nlm.nih.gov/pubmed/26185654 http://dx.doi.org/10.1002/ccr3.285 |
| _version_ | 1782380696521670656 |
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| author | Hochstenbach, Ron Nikkels, Peter G J Elferink, Martin G Oudijk, Martijn A van Oppen, Carla van Zon, Patrick van Harssel, Jeske Schuring-Blom, Heleen Page-Christiaens, Godelieve C M L |
| author_facet | Hochstenbach, Ron Nikkels, Peter G J Elferink, Martin G Oudijk, Martijn A van Oppen, Carla van Zon, Patrick van Harssel, Jeske Schuring-Blom, Heleen Page-Christiaens, Godelieve C M L |
| author_sort | Hochstenbach, Ron |
| collection | PubMed |
| description | Noninvasive prenatal testing (NIPT) and direct karyotyping of cytotrophoblast were normal for a male fetus, but cultured chorionic villus mesenchymal cells and umbilical cord fibroblasts showed nonmosaic trisomy 18. This observation provides direct evidence for the cytotrophoblastic origin of cell-free fetal DNA and yields a biological explanation for falsely reassuring NIPT results. |
| format | Online Article Text |
| id | pubmed-4498868 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2015 |
| publisher | John Wiley & Sons, Ltd |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-44988682015-07-16 Cell-free fetal DNA in the maternal circulation originates from the cytotrophoblast: proof from an unique case Hochstenbach, Ron Nikkels, Peter G J Elferink, Martin G Oudijk, Martijn A van Oppen, Carla van Zon, Patrick van Harssel, Jeske Schuring-Blom, Heleen Page-Christiaens, Godelieve C M L Clin Case Rep Case Reports Noninvasive prenatal testing (NIPT) and direct karyotyping of cytotrophoblast were normal for a male fetus, but cultured chorionic villus mesenchymal cells and umbilical cord fibroblasts showed nonmosaic trisomy 18. This observation provides direct evidence for the cytotrophoblastic origin of cell-free fetal DNA and yields a biological explanation for falsely reassuring NIPT results. John Wiley & Sons, Ltd 2015-06 2015-04-29 /pmc/articles/PMC4498868/ /pubmed/26185654 http://dx.doi.org/10.1002/ccr3.285 Text en © 2015 The Authors. Clinical Case Reports published by John Wiley & Sons Ltd. http://creativecommons.org/licenses/by-nc/4.0/ This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
| spellingShingle | Case Reports Hochstenbach, Ron Nikkels, Peter G J Elferink, Martin G Oudijk, Martijn A van Oppen, Carla van Zon, Patrick van Harssel, Jeske Schuring-Blom, Heleen Page-Christiaens, Godelieve C M L Cell-free fetal DNA in the maternal circulation originates from the cytotrophoblast: proof from an unique case |
| title | Cell-free fetal DNA in the maternal circulation originates from the cytotrophoblast: proof from an unique case |
| title_full | Cell-free fetal DNA in the maternal circulation originates from the cytotrophoblast: proof from an unique case |
| title_fullStr | Cell-free fetal DNA in the maternal circulation originates from the cytotrophoblast: proof from an unique case |
| title_full_unstemmed | Cell-free fetal DNA in the maternal circulation originates from the cytotrophoblast: proof from an unique case |
| title_short | Cell-free fetal DNA in the maternal circulation originates from the cytotrophoblast: proof from an unique case |
| title_sort | cell-free fetal dna in the maternal circulation originates from the cytotrophoblast: proof from an unique case |
| topic | Case Reports |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4498868/ https://www.ncbi.nlm.nih.gov/pubmed/26185654 http://dx.doi.org/10.1002/ccr3.285 |
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