Cargando…

Splicing of a non-coding antisense transcript controls LEF1 gene expression

In this report we have analyzed the role of antisense transcription in the control of LEF1 transcription factor expression. A natural antisense transcript (NAT) is transcribed from a promoter present in the first intron of LEF1 gene and undergoes splicing in mesenchymal cells. Although this locus is...

Descripción completa

Detalles Bibliográficos
Autores principales:	Beltran, Manuel, Aparicio-Prat, Estel, Mazzolini, Rocco, Millanes-Romero, Alba, Massó, Pere, Jenner, Richard G., Díaz, Víctor M., Peiró, Sandra, de Herreros, Antonio García
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2015
Materias:	Gene regulation, Chromatin and Epigenetics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4499130/ https://www.ncbi.nlm.nih.gov/pubmed/25990740 http://dx.doi.org/10.1093/nar/gkv502

Ejemplares similares

Snail1 transcription factor controls telomere transcription and integrity
por: Mazzolini, Rocco, et al.
Publicado: (2018)

A role for YY1 in repression of dominant negative LEF-1 expression in colon cancer
por: Yokoyama, Noriko N., et al.
Publicado: (2010)

Exonic splicing code and protein binding sites for calcium
por: Pengelly, Reuben J, et al.
Publicado: (2022)

Characterization of plastid psbT sense and antisense RNAs
por: Zghidi-Abouzid, Ouafa, et al.
Publicado: (2011)

Sense and antisense transcription are associated with distinct chromatin architectures across genes
por: Murray, Struan C., et al.
Publicado: (2015)

Natural antisense transcripts are significantly involved in regulation of drought stress in maize
por: Xu, Jie, et al.
Publicado: (2017)

Sequence motifs associated with hepatotoxicity of locked nucleic acid—modified antisense oligonucleotides
por: Burdick, Andrew D., et al.
Publicado: (2014)

Antisense transcriptional interference mediates condition-specific gene repression in budding yeast
por: Nevers, Alicia, et al.
Publicado: (2018)

Antisense-mediated repression of SAGA-dependent genes involves the HIR histone chaperone
por: Soudet, Julien, et al.
Publicado: (2022)

SRRM2 organizes splicing condensates to regulate alternative splicing
por: Xu, Shaohai, et al.
Publicado: (2022)

Genome-wide relationship between R-loop formation and antisense transcription in Escherichia coli
por: Raghunathan, Nalini, et al.
Publicado: (2018)

S-box and T-box riboswitches and antisense RNA control a sulfur metabolic operon of Clostridium acetobutylicum
por: André, Gaëlle, et al.
Publicado: (2008)

Role of histone modifications and early termination in pervasive transcription and antisense-mediated gene silencing in yeast
por: Castelnuovo, Manuele, et al.
Publicado: (2014)

Antisense ribosomal siRNAs inhibit RNA polymerase I-directed transcription in C. elegans
por: Liao, Shimiao, et al.
Publicado: (2021)

The fate of notch-1 transcript is linked to cell cycle dynamics by activity of a natural antisense transcript
por: Vujovic, Filip, et al.
Publicado: (2021)

c-MYC empowers transcription and productive splicing of the oncogenic splicing factor Sam68 in cancer
por: Caggiano, Cinzia, et al.
Publicado: (2019)

Histone H1.5 binds over splice sites in chromatin and regulates alternative splicing
por: Glaich, Ohad, et al.
Publicado: (2019)

A pre-initiation complex at the 3′-end of genes drives antisense transcription independent of divergent sense transcription
por: Murray, Struan C., et al.
Publicado: (2012)

Tye7 regulates yeast Ty1 retrotransposon sense and antisense transcription in response to adenylic nucleotides stress
por: Servant, Géraldine, et al.
Publicado: (2012)

ZWC complex-mediated SPT5 phosphorylation suppresses divergent antisense RNA transcription at active gene promoters
por: Park, Kihyun, et al.
Publicado: (2022)

Targeting 3′ and 5′ untranslated regions with antisense oligonucleotides to stabilize frataxin mRNA and increase protein expression
por: Li, Yanjie, et al.
Publicado: (2021)

The organization of nucleosomes around splice sites
por: Chen, Wei, et al.
Publicado: (2010)

A novel antisense long noncoding RNA within the IGF1R gene locus is imprinted in hematopoietic malignancies
por: Sun, Jingnan, et al.
Publicado: (2014)

Rational design of antisense oligonucleotides targeting single nucleotide polymorphisms for potent and allele selective suppression of mutant Huntingtin in the CNS
por: Østergaard, Michael E., et al.
Publicado: (2013)

Upregulation of SPS100 gene expression by an antisense RNA via a switch of mRNA isoforms with different stabilities
por: Bunina, Daria, et al.
Publicado: (2017)

Temporal analyses reveal a pivotal role for sense and antisense enhancer RNAs in coordinate immunoglobulin lambda locus activation
por: Gao, Zeqian, et al.
Publicado: (2023)

Physiological state co-regulates thousands of mammalian mRNA splicing events at tandem splice sites and alternative exons
por: Szafranski, Karol, et al.
Publicado: (2014)

hnRNP G/RBMX enhances HPV16 E2 mRNA splicing through a novel splicing enhancer and inhibits production of spliced E7 oncogene mRNAs
por: Hao, Chengyu, et al.
Publicado: (2022)

Activation of a cryptic 5′ splice site reverses the impact of pathogenic splice site mutations in the spinal muscular atrophy gene
por: Singh, Natalia N., et al.
Publicado: (2017)

Cdk9 and H2Bub1 signal to Clr6-CII/Rpd3S to suppress aberrant antisense transcription
por: Sansó, Miriam, et al.
Publicado: (2020)

The genomic region of the 3′ untranslated region (3′UTR) of PHO84, rather than the antisense RNA, promotes gene repression
por: Hegazy, Youssef A, et al.
Publicado: (2023)

Differential activation mechanisms of two isoforms of Gcr1 transcription factor generated from spliced and un-spliced transcripts in Saccharomyces cerevisiae
por: Cha, Seungwoo, et al.
Publicado: (2020)

Missplicing suppressor alleles of Arabidopsis PRE-MRNA PROCESSING FACTOR 8 increase splicing fidelity by reducing the use of novel splice sites
por: Cabezas-Fuster, Adrián, et al.
Publicado: (2022)

Expression of a large LINE-1-driven antisense RNA is linked to epigenetic silencing of the metastasis suppressor gene TFPI-2 in cancer
por: Cruickshanks, Hazel A., et al.
Publicado: (2013)

Splicing factor and exon profiling across human tissues
por: de la Grange, Pierre, et al.
Publicado: (2010)

CARM1 automethylation is controlled at the level of alternative splicing
por: Wang, Lu, et al.
Publicado: (2013)

The splicing landscape is globally reprogrammed during male meiosis
por: Schmid, Ralf, et al.
Publicado: (2013)

CDK12/13 promote splicing of proximal introns by enhancing the interaction between RNA polymerase II and the splicing factor SF3B1
por: Panzeri, Valentina, et al.
Publicado: (2023)

Sudemycin E influences alternative splicing and changes chromatin modifications
por: Convertini, Paolo, et al.
Publicado: (2014)

A termination-independent role of Rat1 in cotranscriptional splicing
por: Dhoondia, Zuzer, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_prm0h16j551hcoafhp56gnrglo