Stereospecific suppression of active site mutants by methylphosphonate substituted substrates reveals the stereochemical course of site-specific DNA recombination

Tyrosine site-specific recombinases, which promote one class of biologically important phosphoryl transfer reactions in DNA, exemplify active site mechanisms for stabilizing the phosphate transition state. A highly conserved arginine duo (Arg-I; Arg-II) of the recombinase active site plays a crucial...

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Detalles Bibliográficos
Autores principales: Rowley, Paul A., Kachroo, Aashiq H., Ma, Chien-Hui, Maciaszek, Anna D., Guga, Piotr, Jayaram, Makkuni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4499138/
https://www.ncbi.nlm.nih.gov/pubmed/25999343
http://dx.doi.org/10.1093/nar/gkv513

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