Novel mechanism of gene regulation: the protein Rv1222 of Mycobacterium tuberculosis inhibits transcription by anchoring the RNA polymerase onto DNA

We propose a novel mechanism of gene regulation in Mycobacterium tuberculosis where the protein Rv1222 inhibits transcription by anchoring RNA polymerase (RNAP) onto DNA. In contrast to our existing knowledge that transcriptional repressors function either by binding to DNA at specific sequences or...

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Detalles Bibliográficos
Autores principales: Rudra, Paulami, Prajapati, Ranjit Kumar, Banerjee, Rajdeep, Sengupta, Shreya, Mukhopadhyay, Jayanta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4499140/
https://www.ncbi.nlm.nih.gov/pubmed/25999340
http://dx.doi.org/10.1093/nar/gkv516

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4499140/
https://www.ncbi.nlm.nih.gov/pubmed/25999340
http://dx.doi.org/10.1093/nar/gkv516

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