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Rational evolution of Cd(2+)-specific DNAzymes with phosphorothioate modified cleavage junction and Cd(2+) sensing
In vitro selection of RNA-cleaving DNAzymes is a powerful method for isolating metal-specific DNA. A few successful examples are known, but it is still difficult to target some thiophilic metals such as Cd(2+) due to limited functional groups in DNA. While using modified bases expands the chemical f...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Oxford University Press
2015
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4499143/ https://www.ncbi.nlm.nih.gov/pubmed/25990730 http://dx.doi.org/10.1093/nar/gkv519 |