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AP endonuclease 1 prevents trinucleotide repeat expansion via a novel mechanism during base excision repair

Base excision repair (BER) of an oxidized base within a trinucleotide repeat (TNR) tract can lead to TNR expansions that are associated with over 40 human neurodegenerative diseases. This occurs as a result of DNA secondary structures such as hairpins formed during repair. We have previously shown t...

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Detalles Bibliográficos
Autores principales:	Beaver, Jill M., Lai, Yanhao, Xu, Meng, Casin, Astrid H., Laverde, Eduardo E., Liu, Yuan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2015
Materias:	Genome Integrity, Repair and Replication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4499148/ https://www.ncbi.nlm.nih.gov/pubmed/25990721 http://dx.doi.org/10.1093/nar/gkv530

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