Cargando…
DNA-PKcs phosphorylates hnRNP-A1 to facilitate the RPA-to-POT1 switch and telomere capping after replication
The heterogeneous nuclear ribonucleoprotein A1 (hnRNP-A1) has been implicated in telomere protection and telomerase activation. Recent evidence has further demonstrated that hnRNP-A1 plays a crucial role in maintaining newly replicated telomeric 3′ overhangs and facilitating the switch from replicat...
Autores principales: | Sui, Jiangdong, Lin, Yu-Fen, Xu, Kangling, Lee, Kyung-Jong, Wang, Dong, Chen, Benjamin P.C. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4499152/ https://www.ncbi.nlm.nih.gov/pubmed/25999341 http://dx.doi.org/10.1093/nar/gkv539 |
Ejemplares similares
-
TERRA, hnRNP A1, and DNA-PKcs Interactions at Human Telomeres
por: Le, Phuong N., et al.
Publicado: (2013) -
Loss of full-length hnRNP R isoform impairs DNA damage response in motoneurons by inhibiting Yb1 recruitment to chromatin
por: Ghanawi, Hanaa, et al.
Publicado: (2021) -
DNA-PKcs is required to maintain stability of Chk1 and Claspin for optimal replication stress response
por: Lin, Yu-Fen, et al.
Publicado: (2014) -
Tel1 and Rad51 are involved in the maintenance of telomeres with capping deficiency
por: Di Domenico, Enea Gino, et al.
Publicado: (2013) -
Pot1 inactivation leads to rampant telomere resection and loss in one cell cycle
por: Pitt, Christopher W., et al.
Publicado: (2010)