Real-time single-molecule studies of the motions of DNA polymerase fingers illuminate DNA synthesis mechanisms

DNA polymerases maintain genomic integrity by copying DNA with high fidelity. A conformational change important for fidelity is the motion of the polymerase fingers subdomain from an open to a closed conformation upon binding of a complementary nucleotide. We previously employed intra-protein single...

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Detalles Bibliográficos
Autores principales: Evans, Geraint W., Hohlbein, Johannes, Craggs, Timothy, Aigrain, Louise, Kapanidis, Achillefs N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4499156/
https://www.ncbi.nlm.nih.gov/pubmed/26013816
http://dx.doi.org/10.1093/nar/gkv547

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