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Higher plasma prorenin concentration plays a role in the development of coronary artery disease

BACKGROUND: Prorenin and renin are both involved in atherosclerosis. However, the role of plasma prorenin and renin in the development and progression of coronary artery disease (CAD) is still not clear. Thus, we aimed to examine the relationships among plasma prorenin concentration, CAD and clinica...

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Autores principales: Yoshida, Gakuro, Kawasaki, Masanori, Murata, Ichijiro, Hayakawa, Yuka, Aoyama, Takuma, Miyazaki, Nagisa, Yamada, Yoshihisa, Nishigaki, Kazuhiko, Arai, Yoshie, Suzuki, Fumiaki, Minatoguchi, Shinya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4499175/
https://www.ncbi.nlm.nih.gov/pubmed/26167285
http://dx.doi.org/10.1186/s40364-015-0044-1
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author Yoshida, Gakuro
Kawasaki, Masanori
Murata, Ichijiro
Hayakawa, Yuka
Aoyama, Takuma
Miyazaki, Nagisa
Yamada, Yoshihisa
Nishigaki, Kazuhiko
Arai, Yoshie
Suzuki, Fumiaki
Minatoguchi, Shinya
author_facet Yoshida, Gakuro
Kawasaki, Masanori
Murata, Ichijiro
Hayakawa, Yuka
Aoyama, Takuma
Miyazaki, Nagisa
Yamada, Yoshihisa
Nishigaki, Kazuhiko
Arai, Yoshie
Suzuki, Fumiaki
Minatoguchi, Shinya
author_sort Yoshida, Gakuro
collection PubMed
description BACKGROUND: Prorenin and renin are both involved in atherosclerosis. However, the role of plasma prorenin and renin in the development and progression of coronary artery disease (CAD) is still not clear. Thus, we aimed to examine the relationships among plasma prorenin concentration, CAD and clinical parameters. METHODS: We measured plasma prorenin and renin concentrations and other parameters in 85 patients who underwent coronary angiography. Patients were divided into a CAD group (≥75 % stenosis in one or more coronary arteries) and a non-CAD group. RESULTS: There was a weak correlation between prorenin and plasma renin concentration (r =0.35, p =0.001), and plasma renin activity (r =0.34, p =0.001). There was no significant difference in the plasma prorenin concentration between the CAD group and non-CAD group. However, patients with a high plasma prorenin concentration frequently suffered CAD. Receiver-operating-characteristic curve analysis showed that the optimal cutoff value of plasma prorenin concentration to detect CAD was 1,100 pg/ml, with a positive predictive value of 94 % and a negative predictive value of 36 %. CONCLUSION: The plasma prorenin concentration increases with increases in plasma renin concentration. Higher plasma prorenin concentration (>1,100 pg/ml) plays a role in the development of CAD.
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spelling pubmed-44991752015-07-12 Higher plasma prorenin concentration plays a role in the development of coronary artery disease Yoshida, Gakuro Kawasaki, Masanori Murata, Ichijiro Hayakawa, Yuka Aoyama, Takuma Miyazaki, Nagisa Yamada, Yoshihisa Nishigaki, Kazuhiko Arai, Yoshie Suzuki, Fumiaki Minatoguchi, Shinya Biomark Res Research BACKGROUND: Prorenin and renin are both involved in atherosclerosis. However, the role of plasma prorenin and renin in the development and progression of coronary artery disease (CAD) is still not clear. Thus, we aimed to examine the relationships among plasma prorenin concentration, CAD and clinical parameters. METHODS: We measured plasma prorenin and renin concentrations and other parameters in 85 patients who underwent coronary angiography. Patients were divided into a CAD group (≥75 % stenosis in one or more coronary arteries) and a non-CAD group. RESULTS: There was a weak correlation between prorenin and plasma renin concentration (r =0.35, p =0.001), and plasma renin activity (r =0.34, p =0.001). There was no significant difference in the plasma prorenin concentration between the CAD group and non-CAD group. However, patients with a high plasma prorenin concentration frequently suffered CAD. Receiver-operating-characteristic curve analysis showed that the optimal cutoff value of plasma prorenin concentration to detect CAD was 1,100 pg/ml, with a positive predictive value of 94 % and a negative predictive value of 36 %. CONCLUSION: The plasma prorenin concentration increases with increases in plasma renin concentration. Higher plasma prorenin concentration (>1,100 pg/ml) plays a role in the development of CAD. BioMed Central 2015-07-11 /pmc/articles/PMC4499175/ /pubmed/26167285 http://dx.doi.org/10.1186/s40364-015-0044-1 Text en © Yoshida et al. 2015 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Yoshida, Gakuro
Kawasaki, Masanori
Murata, Ichijiro
Hayakawa, Yuka
Aoyama, Takuma
Miyazaki, Nagisa
Yamada, Yoshihisa
Nishigaki, Kazuhiko
Arai, Yoshie
Suzuki, Fumiaki
Minatoguchi, Shinya
Higher plasma prorenin concentration plays a role in the development of coronary artery disease
title Higher plasma prorenin concentration plays a role in the development of coronary artery disease
title_full Higher plasma prorenin concentration plays a role in the development of coronary artery disease
title_fullStr Higher plasma prorenin concentration plays a role in the development of coronary artery disease
title_full_unstemmed Higher plasma prorenin concentration plays a role in the development of coronary artery disease
title_short Higher plasma prorenin concentration plays a role in the development of coronary artery disease
title_sort higher plasma prorenin concentration plays a role in the development of coronary artery disease
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4499175/
https://www.ncbi.nlm.nih.gov/pubmed/26167285
http://dx.doi.org/10.1186/s40364-015-0044-1
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